Application of Intraoperative Radiotherapy in Early-Stage Breast Cancer Patients in a Clinical Setting.

Autor: Wang A; Medical School for International Health Ben-Gurion University of the Negev, Be'er Sheva 8410501, Israel., Quint E; Department of General Surgery B Soroka University Medical Center, Be'er Sheva 8410101, Israel., Kukeev I; Department of General Surgery B Soroka University Medical Center, Be'er Sheva 8410101, Israel., Agassi R; Center Surgical Oncology of Breast Soroka University Medical Center, Be'er Sheva 8410101, Israel., Belochitski O; Radiation Oncology Unit Soroka University Medical Center, Be'er Sheva, Israel., Barski G; Department of General Surgery B Soroka University Medical Center, Be'er Sheva 8410101, Israel., Vaynshtein J; Department of General Surgery B Soroka University Medical Center, Be'er Sheva 8410101, Israel.
Jazyk: angličtina
Zdroj: International journal of breast cancer [Int J Breast Cancer] 2024 Jun 18; Vol. 2024, pp. 5551907. Date of Electronic Publication: 2024 Jun 18 (Print Publication: 2024).
DOI: 10.1155/2024/5551907
Abstrakt: Background: Intraoperative radiation therapy (IORT) has gained popularity in recent years as an alternative to external beam whole breast radiation therapy (WBRT) for early-stage breast cancer. Here, we report 43-month recurrence and survival outcomes in a multiethnic cohort treated with IORT in a clinical context. Method: Two hundred and eleven patients with low-risk features were treated with IORT for early-stage breast cancer from 2014 to 2021. Selection criteria were based on Group Europeen de Curietherapie-European Society for Therapeutic Radiology and Oncology (GEC-ESTRO) guidelines: preferably unifocal intraductal carcinoma (IDC), aged > 50, tumor size ≤ 2.0 cm, and without lymph node involvement. All patients received 20 Gy of radiation dose during the lumpectomy. Information on patient and tumor characteristics was collected. Results: The mean age of this cohort was 67.5 years; 95.2% of patients are Jewish, and the rest are Bedouins (4.7%). Most tumors were intraductal carcinoma (97.2%) and stage 1 (94.8%). The mean follow-up time was 43.4 months. Bedouins had larger tumor sizes (mean 1.21 vs. 1.13 cm) and were younger at diagnosis than Jewish patients (mean 65.4 vs. 67.6 years), although the differences are not significant. The overall recurrence rate was 1.4%. One case of local recurrence (0.5%) and two cases of metastasis (0.9%) were observed during the study period. One patient died from metastasis. Conclusion: Our findings suggest that IORT in selected low-risk patients can achieve an excellent prognosis with low rates of recurrence and metastasis.
Competing Interests: The authors declare no conflicts of interest.
(Copyright © 2024 Ao Wang et al.)
Databáze: MEDLINE
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