Functional infrared thermography imaging can be used to assess the effectiveness of Maxicam Gel ® in pre-emptively treating transient synovitis and lameness in horses.
| Autor: | de Carvalho JRG; Laboratory of Equine Exercise Physiology and Pharmacology (LAFEQ), Department of Animal Morphology and Physiology, School of Agricultural and Veterinary Sciences, São Paulo State University, FCAV/UNESP, São Paulo, Brazil., Del Puppo D; Research and Development Department, Ourofino Animal Health Company, São Paulo, Brazil., Littiere TO; Laboratory of Equine Exercise Physiology and Pharmacology (LAFEQ), Department of Animal Morphology and Physiology, School of Agricultural and Veterinary Sciences, São Paulo State University, FCAV/UNESP, São Paulo, Brazil., de Sales NAA; Laboratory of Equine Exercise Physiology and Pharmacology (LAFEQ), Department of Animal Morphology and Physiology, School of Agricultural and Veterinary Sciences, São Paulo State University, FCAV/UNESP, São Paulo, Brazil., Silva ACY; Laboratory of Equine Exercise Physiology and Pharmacology (LAFEQ), Department of Animal Morphology and Physiology, School of Agricultural and Veterinary Sciences, São Paulo State University, FCAV/UNESP, São Paulo, Brazil., Ribeiro G; Veterinary and Animal Research Centre (CECAV), Faculty of Veterinary Medicine, Lusófona University - Lisbon University Centre, Lisbon, Portugal., de Almeida FN; Research and Development Department, Ourofino Animal Health Company, São Paulo, Brazil., Alves BG; Research and Development Department, Ourofino Animal Health Company, São Paulo, Brazil., Gatto IRH; Research and Development Department, Ourofino Animal Health Company, São Paulo, Brazil., Ramos GV; Equine Sports Medicine Laboratory, Department of Veterinary Medicine and Surgery, School of Agricultural and Veterinary Sciences, São Paulo State University, FCAV/UNESP, São Paulo, Brazil., Ferraz GC; Laboratory of Equine Exercise Physiology and Pharmacology (LAFEQ), Department of Animal Morphology and Physiology, School of Agricultural and Veterinary Sciences, São Paulo State University, FCAV/UNESP, São Paulo, Brazil. |
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| Jazyk: | angličtina |
| Zdroj: | Frontiers in veterinary science [Front Vet Sci] 2024 Jun 11; Vol. 11, pp. 1399815. Date of Electronic Publication: 2024 Jun 11 (Print Publication: 2024). |
| DOI: | 10.3389/fvets.2024.1399815 |
| Abstrakt: | Introduction: Diagnosing and treating lameness in horses is essential to improving their welfare. In equine orthopedic practice, infrared thermography (IRT) can indirectly detect soreness. Non-steroidal anti-inflammatory drugs can treat painful and inflammatory processes in horses. Using IRT, the efficacy of meloxicam (Maxicam Gel ® ) was evaluated in pre-treating transient synovitis in horses induced by a middle carpal joint injection of lipopolysaccharides (LPS) from E. coli 055:B5 at a dose of 10 endotoxin units. Methods: In a cross-over design, six healthy horses were randomly assigned to receive either 0.6 mg/kg of oral Maxicam Gel ® (MAXVO) or a mock administration (control group, C) following a two-week washout period. IRT of the middle carpal joint, visual lameness assessment and joint circumference were recorded over time. Clinical and hematological evaluations were performed. Synovial fluid aspirates were analyzed for total nucleated cell count, total protein, and prostaglandin E Results: There were no changes in joint circumference. The MAXVO group showed a lower rectal temperature 4 h after synovitis induction. The C group presented an increase in neutrophils and a decrease in total hemoglobin and hematocrit 8 h after induction. No changes were observed in the synovial fluid between groups. The horses that received meloxicam did not show clinically significant lameness at any time, while the C group showed an increase in lameness 2, 4, and 8 h after synovitis induction. Discussion: IRT indicated that the skin surface temperature of the middle carpal joint was lower in horses who received meloxicam, suggesting a reduction in the inflammatory process induced by LPS. It was observed that the maximum temperature peaks in the dorsopalmar and lateropalmar positions can be utilized to predict the severity of lameness, particularly when the temperature rises above 34°C. Horses pre-treated with meloxicam showed either reduced or no indication of mild to moderate pain and presented a lowehr thermographic temperature, which indicates the effectiveness of Maxicam Gel ® as an anti-inflammatory. Competing Interests: DD, FA, BA, and IG were employed by company Ourofino Animal Health Company. The authors declare that this study received funding from Ourofino Animal Health Company. The funder was involved in the study’s design, writing of this article, and the decision to submit it for publication. The meloxicam was formulated and manufactured by Ourofino Animal Health Company for commercial use in Brazil, and the study was designed to meet Brazilian regulations. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2024 Carvalho, Del Puppo, Littiere, Sales, Silva, Ribeiro, Almeida, Alves, Gatto, Ramos and Ferraz.) |
| Databáze: | MEDLINE |
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