Association of HLA class II gene polymorphisms and expression levels of ORAI1/STIM1 genes in HIV-1‒positive patients with HIV-related dermatoses in Latvia.
| Autor: | Soha A; Doctoral program, Riga Stradiņš University, Riga, Latvia., Azina I; Latvian Center for Infectious Diseases, Riga East University Hospital, Riga, Latvia., Miskina DA; Residency program, University of Latvia, Riga, Latvia., Murasko V; Residency program, University of Latvia, Riga, Latvia., Zolovs M; Statistics Unit, Riga Stradiņš University, Riga, Latvia.; Institute of Life Sciences and Technology, Daugavpils University, Daugavpils, Latvia., Rubins A; Faculty of Medicine, University of Latvia, Riga, Latvia. |
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| Jazyk: | angličtina |
| Zdroj: | Acta dermatovenerologica Alpina, Pannonica, et Adriatica [Acta Dermatovenerol Alp Pannonica Adriat] 2024 Jun; Vol. 33 (2), pp. 89-94. |
| Abstrakt: | Introduction: This study explores the immunogenetic associations of human leukocyte antigens (HLA) and the calcium release-activated calcium modulator 1 (ORAI1) and stromal interaction molecule 1 (STIM1) genes in HIV-1‒positive patients with HIV-related skin disorders. Methods: This study assessed the distribution of variants of HLA class II alleles and expression levels of ORAI1 and STIM1 genes in the blood between HIV-1‒positive patients with HIV-related skin disorders and the control group with no HIV within the Latvian population. Results: The research group comprised 115 HIV-1‒positive patients with HIV-related skin disorders, and the control group included 80 healthy individuals. Risk alleles (HLA- DQB1*02:01-0301 and HLA-DQA1*01:01-0501) and protective alleles (HLA-DRB1*07-13, DRB1*01-13, DRB1*04-11, and HLA-DQA1*05:01-0501) showed statistical significance in the groups. In 38 out of 115 patients, higher expression levels of ORAI1 and STIM1 genes were detected in the blood at the beginning of treatment. A significantly higher level of the microribonucleic acid (mRNA) ORAI1 gene was also found in the control group. Conclusions: The results demonstrate that HLA class II alleles are associated with a trend toward risk/protection concerning HIV-related skin disorders in HIV-1‒positive patients. It was also shown that a low level of ORAI1 mRNA and the risk allele HLA-DQB1*0201-0301 were simultaneously present in the research group. |
| Databáze: | MEDLINE |
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