Diabetes mellitus and risk of incident dementia in APOE ɛ4 carriers: an updated meta-analysis.

Autor: Rashtchian A; Student Research Committee, School of Medicine, Shahid Beheshti University of Medical Sciences, SBUMS, Arabi Ave, Daneshjoo Blvd, Velenjak, Tehran, 19839-63113, Iran., Etemadi MH; Students Research Committee, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran., Asadi E; Student Research Committee, School of Medicine, Shahid Beheshti University of Medical Sciences, SBUMS, Arabi Ave, Daneshjoo Blvd, Velenjak, Tehran, 19839-63113, Iran., Binaei S; Endocrinology and Metabolism Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, Iran., Abbasi M; Student Research Committee, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran., Bayani M; Student Research Committee,, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Izadi E; Student Research Committee, School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran., Sadat-Madani SF; Medical Doctor, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran., Naziri M; Student Research Committee, School of Health, Iran University of Medical Science, Tehran, Iran., Khoshravesh S; Shahid Beheshti University of Medical Sciences, Tehran, Iran., Shirani M; Student Research Committee, School of Medicine, Shahid Beheshti University of Medical Sciences, SBUMS, Arabi Ave, Daneshjoo Blvd, Velenjak, Tehran, 19839-63113, Iran., Asadi Anar M; Student Research Committee, School of Medicine, Shahid Beheshti University of Medical Sciences, SBUMS, Arabi Ave, Daneshjoo Blvd, Velenjak, Tehran, 19839-63113, Iran. Mahsa.boz@gmail.com., Deravi N; Student Research Committee, School of Medicine, Shahid Beheshti University of Medical Sciences, SBUMS, Arabi Ave, Daneshjoo Blvd, Velenjak, Tehran, 19839-63113, Iran. Niloofarderavi@sbmu.ac.ir.
Jazyk: angličtina
Zdroj: BMC neuroscience [BMC Neurosci] 2024 Jun 25; Vol. 25 (1), pp. 28. Date of Electronic Publication: 2024 Jun 25.
DOI: 10.1186/s12868-024-00878-9
Abstrakt: Background and Aim: Diabetes raises the risk of dementia, mortality, and cognitive decline in the elderly, potentially because of hereditary variables such as APOE. In this study, we aim to evaluate Diabetes mellitus and the risk of incident dementia in APOE ɛ4 carriers.
Method: We thoroughly searched PubMed (Medline), Scopus, and Google Scholar databases for related articles up to September 2023. The titles, abstracts, and full texts of articles were reviewed; data were extracted and analyzed.
Result: This meta-analysis included nine cohorts and seven cross-sectional articles with a total of 42,390 population. The study found that APOE ɛ4 carriers with type 2 diabetes (T2D) had a 48% higher risk of developing dementia compared to non-diabetic carriers (Hazard Ratio;1.48, 95%CI1.36-1.60). The frequency of dementia was 3 in 10 people (frequency: 0.3; 95%CI (0.15-0.48). No significant heterogeneity was observed. Egger's test, which we performed, revealed no indication of publication bias among the included articles (p = 0.2).
Conclusion: Overall, diabetes increases the risk of dementia, but further large-scale studies are still required to support the results of current research.
(© 2024. The Author(s).)
Databáze: MEDLINE
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