The balance of STING signaling orchestrates immunity in cancer.

Autor: Lanng KRB; Department of Biomedicine, Aarhus University, Aarhus, Denmark., Lauridsen EL; Department of Biomedicine, Aarhus University, Aarhus, Denmark., Jakobsen MR; Department of Biomedicine, Aarhus University, Aarhus, Denmark. mrj@biomed.au.dk.
Jazyk: angličtina
Zdroj: Nature immunology [Nat Immunol] 2024 Jul; Vol. 25 (7), pp. 1144-1157. Date of Electronic Publication: 2024 Jun 25.
DOI: 10.1038/s41590-024-01872-3
Abstrakt: Over the past decade, it has become clear that the stimulator of interferon genes (STING) pathway is critical for a variety of immune responses. This endoplasmic reticulum-anchored adaptor protein has regulatory functions in host immunity across a spectrum of conditions, including infectious diseases, autoimmunity, neurobiology and cancer. In this Review, we outline the central importance of STING in immunological processes driven by expression of type I and III interferons, as well as inflammatory cytokines, and we look at therapeutic options for targeting STING. We also examine evidence that challenges the prevailing notion that STING activation is predominantly beneficial in combating cancer. Further exploration is imperative to discern whether STING activation in the tumor microenvironment confers true benefits or has detrimental effects. Research in this field is at a crossroads, as a clearer understanding of the nuanced functions of STING activation in cancer is required for the development of next-generation therapies.
(© 2024. Springer Nature America, Inc.)
Databáze: MEDLINE
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