The pathobiology of human fungal infections.

Autor: Brown GD; Medical Research Council Centre for Medical Mycology, University of Exeter, Exeter, UK. gordon.brown@exeter.ac.uk., Ballou ER; Medical Research Council Centre for Medical Mycology, University of Exeter, Exeter, UK., Bates S; Medical Research Council Centre for Medical Mycology, University of Exeter, Exeter, UK., Bignell EM; Medical Research Council Centre for Medical Mycology, University of Exeter, Exeter, UK., Borman AM; Medical Research Council Centre for Medical Mycology, University of Exeter, Exeter, UK., Brand AC; Medical Research Council Centre for Medical Mycology, University of Exeter, Exeter, UK., Brown AJP; Medical Research Council Centre for Medical Mycology, University of Exeter, Exeter, UK., Coelho C; Medical Research Council Centre for Medical Mycology, University of Exeter, Exeter, UK., Cook PC; Medical Research Council Centre for Medical Mycology, University of Exeter, Exeter, UK., Farrer RA; Medical Research Council Centre for Medical Mycology, University of Exeter, Exeter, UK., Govender NP; Medical Research Council Centre for Medical Mycology, University of Exeter, Exeter, UK., Gow NAR; Medical Research Council Centre for Medical Mycology, University of Exeter, Exeter, UK., Hope W; Medical Research Council Centre for Medical Mycology, University of Exeter, Exeter, UK., Hoving JC; Medical Research Council Centre for Medical Mycology, University of Exeter, Exeter, UK., Dangarembizi R; Medical Research Council Centre for Medical Mycology, University of Exeter, Exeter, UK., Harrison TS; Medical Research Council Centre for Medical Mycology, University of Exeter, Exeter, UK., Johnson EM; Medical Research Council Centre for Medical Mycology, University of Exeter, Exeter, UK., Mukaremera L; Medical Research Council Centre for Medical Mycology, University of Exeter, Exeter, UK., Ramsdale M; Medical Research Council Centre for Medical Mycology, University of Exeter, Exeter, UK., Thornton CR; Medical Research Council Centre for Medical Mycology, University of Exeter, Exeter, UK., Usher J; Medical Research Council Centre for Medical Mycology, University of Exeter, Exeter, UK., Warris A; Medical Research Council Centre for Medical Mycology, University of Exeter, Exeter, UK., Wilson D; Medical Research Council Centre for Medical Mycology, University of Exeter, Exeter, UK.
Jazyk: angličtina
Zdroj: Nature reviews. Microbiology [Nat Rev Microbiol] 2024 Nov; Vol. 22 (11), pp. 687-704. Date of Electronic Publication: 2024 Jun 25.
DOI: 10.1038/s41579-024-01062-w
Abstrakt: Human fungal infections are a historically neglected area of disease research, yet they cause more than 1.5 million deaths every year. Our understanding of the pathophysiology of these infections has increased considerably over the past decade, through major insights into both the host and pathogen factors that contribute to the phenotype and severity of these diseases. Recent studies are revealing multiple mechanisms by which fungi modify and manipulate the host, escape immune surveillance and generate complex comorbidities. Although the emergence of fungal strains that are less susceptible to antifungal drugs or that rapidly evolve drug resistance is posing new threats, greater understanding of immune mechanisms and host susceptibility factors is beginning to offer novel immunotherapeutic options for the future. In this Review, we provide a broad and comprehensive overview of the pathobiology of human fungal infections, focusing specifically on pathogens that can cause invasive life-threatening infections, highlighting recent discoveries from the pathogen, host and clinical perspectives. We conclude by discussing key future challenges including antifungal drug resistance, the emergence of new pathogens and new developments in modern medicine that are promoting susceptibility to infection.
(© 2024. Springer Nature Limited.)
Databáze: MEDLINE
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