Late onset epilepsy and stroke: Diagnosis, pathogenesis and prevention.

Autor: Stefan H; Department of Neurology, Biomagnetism, University Hospital Erlangen, Germany; Private Practice, 50, Allee am Röthelheimpark, Erlangen, Germany. Electronic address: Hermann.stefan@t-online.de., Michelson G; Department of Ophthalmology, University Hospital Erlangen, Germany; Private Practice, Parcside, 2, Am Stadtpark, Nuremberg, Germany.
Jazyk: angličtina
Zdroj: Seizure [Seizure] 2024 Jun 12. Date of Electronic Publication: 2024 Jun 12.
DOI: 10.1016/j.seizure.2024.06.011
Abstrakt: The association of stroke and late-onset epilepsy (LOE) is discussed with special regard to its diagnosis, pathogenesis, and prevention. In addition to epidemiological data, including those from different age groups, the mechanisms for the development of acute symptomatic and remote symptomatic seizures are reviewed. The risk factors associated with seizures and post-stroke epilepsy (PSE) are considered, along with the methodological limitations of the study. For future research, the distinction between acute and remote symptomatic seizure before or after seven days from stroke onset should be reviewed because different acute symptomatic seizures (ASSs) themselves can entail a variable PSE risk. The definition of LOE by age is hitherto inconsistent. Comparing adult lifespan epochs, it is evident that stroke and seizures exhibit similar prevalence profiles. Young adulthood, old adulthood, and elderly epochs may be relevant for the differentiation of LOE subtype by age, vascular comorbidity, and other characteristics. A step-scheme strategy as a possible contribution to cerebrovascular prevention approaches is proposed.
Competing Interests: Declaration of competing interest Hermann Stefan received travel reimbursement and honoraria for lectures from Desitin and Eisai. Otherwise both authors report no conflict of interest.
(Copyright © 2024. Published by Elsevier Ltd.)
Databáze: MEDLINE
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