Ambient exposure to fine particulate matter with oxidative potential affects oxidative stress biomarkers in pregnancy.

Autor:	Meng Q; Department of Epidemiology, Fielding School of Public Health, University of California, Los Angeles, CA 90095, USA., Liu J; Department of Environmental Health Sciences, Fielding School of Public Health, University of California, Los Angeles, CA 90095, USA., Shen J; Department of Atmospheric & Oceanic Sciences, University of California, Los Angeles, CA 90095, USA., Del Rosario I; Department of Epidemiology, Fielding School of Public Health, University of California, Los Angeles, CA 90095, USA., Janzen C; Department of Obstetrics & Gynecology, University of California, Los Angeles, CA 90095, USA., Devaskar SU; Department of Pediatrics, University of California, Los Angeles, CA 90095, USA., Lakey PSJ; Department of Chemistry, University of California, Irvine, CA 92697, USA., Shiraiwa M; Department of Chemistry, University of California, Irvine, CA 92697, USA., Weichenthal S; Department of Epidemiology, Biostatistics, and Occupational Health, McGill University, Montreal, Quebec H3A 1A2, Canada., Zhu Y; Department of Environmental Health Sciences, Fielding School of Public Health, University of California, Los Angeles, CA 90095, USA., Oroumiyeh F; Department of Environmental Health Sciences, Fielding School of Public Health, University of California, Los Angeles, CA 90095, USA., Banerjee S; Department of Biostatistics, Fielding School of Public Health, University of California, Los Angeles, CA 90095, USA., Paulson SE; Department of Atmospheric & Oceanic Sciences, University of California, Los Angeles, CA 90095, USA., Jerrett M; Department of Environmental Health Sciences, Fielding School of Public Health, University of California, Los Angeles, CA 90095, USA., Paul KC; Department of Neurology, University of California, Los Angeles, CA 90095, USA., Ritz B; Department of Epidemiology, Fielding School of Public Health, University of California, Los Angeles, CA 90095, USA.
Jazyk:	angličtina
Zdroj:	American journal of epidemiology [Am J Epidemiol] 2024 Jun 25. Date of Electronic Publication: 2024 Jun 25.
DOI:	10.1093/aje/kwae152
Abstrakt:	Prenatal exposures to ambient particulate matter (PM2.5) from traffic may generate oxidative stress, and thus contribute to adverse birth outcomes. We investigated whether PM2.5 constituents from brake and tire wear affect levels of oxidative stress biomarkers (malondialdehyde (MDA), 8-hydroxy-2'-deoxyguanosine (8-OHdG)) using urine samples collected up to three times during pregnancy in 156 women recruited from antenatal clinics at the University of California Los Angeles. Land use regression models with co-kriging were employed to estimate average residential outdoor concentrations of black carbon (BC), PM2.5 mass, PM2.5 metal components, and three PM2.5 oxidative potential metrics during the 4-weeks prior to urine sample collection. 8-OHdG concentrations in mid-pregnancy increased by 24.8% (95% CI: 9.0, 42.8) and 14.3% (95% CI: 0.4%, 30.0%) per interquartile range (IQR) increase in PM2.5 mass and BC, respectively. The brake wear marker (barium) and the oxidative potential metrics were associated with increased MDA concentration in the 1st sample collected (10-17 gestational week), but 95% CIs included the null. Traffic-related air pollution contributed in early to mid-pregnancy to oxidative stress generation previously linked to adverse birth outcomes. (© The Author(s) 2024. Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
Databáze:	MEDLINE
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