Degradation of the mechanical properties of cortical bone due to long duration storage.

Autor: Daras N; Blast Impact and Survivability Research Unit (BISRU), Mechanical Engineering, University of Cape Town, Cape Town, 7701, Western Cape, South Africa., Nurick GN; Blast Impact and Survivability Research Unit (BISRU), Mechanical Engineering, University of Cape Town, Cape Town, 7701, Western Cape, South Africa., Cloete TJ; Blast Impact and Survivability Research Unit (BISRU), Mechanical Engineering, University of Cape Town, Cape Town, 7701, Western Cape, South Africa. Electronic address: trevor.cloete@uct.ac.za.
Jazyk: angličtina
Zdroj: Journal of the mechanical behavior of biomedical materials [J Mech Behav Biomed Mater] 2024 Sep; Vol. 157, pp. 106632. Date of Electronic Publication: 2024 Jun 20.
DOI: 10.1016/j.jmbbm.2024.106632
Abstrakt: Understanding the behaviour and material properties of bone is critical in predicting the failure and fracture of bones in humans. To address this, mechanical tests have traditionally been conducted to characterize bone material and this has resulted in large body of literature. However, there appears to be a lack of complete information regarding the storage protocols used for bone specimens prior to conducting mechanical tests. For example, while storage methods are well described, parameters such as the time between donor death and bone retrieval, as well as time between specimen machining and testing, are seldom reported. As biological materials undergo degradation in storage after being removed from the donor, a clear understanding of this degradation behaviour would identify critical time frames in which previously stored cortical bone specimens should be tested such that they can still be considered representative of an in-vivo condition. In this paper, the results of an investigation to determine the effects of long duration storage on the measured mechanical properties of bovine cortical bone are reported. Three different storage protocols are compared; namely machined-refrigerated, machined-frozen and frozen-machined-frozen. Degradation effects are evident for both refrigerated and frozen specimens and the results demonstrate that testing bone specimens after more than one week in storage may not provide representative in-vivo properties. In addition, specimens exhibit severe degradation after six months in storage regardless of the storage protocol.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 The Author(s). Published by Elsevier Ltd.. All rights reserved.)
Databáze: MEDLINE
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