Effects of Cardiopulmonary Rehabilitation on Cardiorespiratory Fitness and Clinical Symptom Burden in Long COVID: Results from the COVID-Rehab Randomized Controlled Trial.

Autor:	Besnier F, Malo J, Mohammadi H, Clavet S, Klai C; Research center and Centre ÉPIC, Montreal Heart Institute, Montréal H1T 1N6, Québec, Canada., Martin N; Research center and Centre ÉPIC, Montreal Heart Institute, Montréal H1T 1N6, Québec, Canada., Bérubé B, Lecchino C, Iglesies-Grau J, Vincent T; Research center and Centre ÉPIC, Montreal Heart Institute, Montréal H1T 1N6, Québec, Canada., Gagnon C; Research center and Centre ÉPIC, Montreal Heart Institute, Montréal H1T 1N6, Québec, Canada., Gaudreau-Majeau F; Department of Psychology, Université de Montréal, Montréal H3C 3J7, Québec, Canada., Juneau M, Simard F, L'Allier P, Nigam A, Gayda M, Bherer L
Jazyk:	angličtina
Zdroj:	American journal of physical medicine & rehabilitation [Am J Phys Med Rehabil] 2024 Jun 24. Date of Electronic Publication: 2024 Jun 24.
DOI:	10.1097/PHM.0000000000002559
Abstrakt:	Objective: To investigate the effectiveness of an eight-week cardiopulmonary rehabilitation program on cardiorespiratory fitness (VO2peak) and key cardiopulmonary exercise test measures, quality of life, and symptom burden in individuals with Long COVID. Design: Forty individuals with Long COVID (mean age 53 ± 11 years), were randomized into 2 groups: 1/ Rehabilitation group: centre-based individualized clinical rehabilitation program (8 weeks, 3 sessions per week of aerobic and resistance exercises, and daily inspiratory muscle training) and 2/ Control group: individuals maintained their daily habits during an eight-week period. Results: There was a significant difference between groups in mean VO2peak improvement (p = 0.003). VO2peak improved significantly in the rehab group (+2.7 mL.kg.min 95%IC:+1.6 to +3.8 p < 0.001) compared to the control group (+0.3 mL.kg.min 95%IC:-0.8 to +1.3 p = 0.596), along withVE/VCO2 slope (p = 0.032) (-2.4 95%IC:-4.8 to +0.01 p = 0.049 and + 1.3 95%IC:-1.0 to +3.6 p = 0.272 respectively) and VO2 at first ventilatory threshold (p = 0.045). Furthermore, all symptom impact scales improved significantly in the rehabilitation group compared to the control group (p < 0.05). Conclusion: An individualized and supervised cardiopulmonary rehabilitation program was effective in improving cardiorespiratory fitness, ventilatory efficiency, and symptom burden in individuals with Long COVID. Careful monitoring of symptoms is important to appropriately tailor and adjust rehabilitation sessions. Competing Interests: Conflicts of Interest: The authors have no actual or potential conflicts of interest related to this manuscript. (Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.)
Databáze:	MEDLINE
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