Cognitive functions and the brain-derived neurotrophic factor in patients with mild autonomous cortisol secretion.

Autor:	Barlas T; Faculty of Medicine, Department of Endocrinology and Metabolism, Gazi University, 06500 Ankara, Turkey., Aksu MH; Faculty of Medicine, Department of Psychiatry, Gazi University, 06500 Ankara, Turkey., Cerit ET; Faculty of Medicine, Department of Endocrinology and Metabolism, Gazi University, 06500 Ankara, Turkey., Yalcin MM; Faculty of Medicine, Department of Endocrinology and Metabolism, Gazi University, 06500 Ankara, Turkey., Akturk M; Faculty of Medicine, Department of Endocrinology and Metabolism, Gazi University, 06500 Ankara, Turkey., Balos Toruner F; Faculty of Medicine, Department of Endocrinology and Metabolism, Gazi University, 06500 Ankara, Turkey., Karakoc MA; Faculty of Medicine, Department of Endocrinology and Metabolism, Gazi University, 06500 Ankara, Turkey., Eroglu Altinova A; Faculty of Medicine, Department of Endocrinology and Metabolism, Gazi University, 06500 Ankara, Turkey.
Jazyk:	angličtina
Zdroj:	European journal of endocrinology [Eur J Endocrinol] 2024 Jul 02; Vol. 191 (1), pp. 31-37.
DOI:	10.1093/ejendo/lvae070
Abstrakt:	Context: The impact of abnormal cortisol secretion on cognitive functions in patients with mild autonomous cortisol secretion (MACS) remains uncertain. Objective: To assess cognitive functions, determine serum brain-derived neurotrophic factor (BDNF) concentration in patients with MACS, and investigate the association between cognitive subdomains and BDNF. Methods: We prospectively recruited 84 participants-28 patients with MACS, 28 patients with nonfunctional adrenal adenoma (NFAA), and 28 control subjects matched for age, gender, body mass index (BMI), visceral adiposity, and educational level. The serum BDNF concentration of participants was measured. The Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition-focused interviews and Montreal Cognitive Assessments (MoCA) were carried out by an experienced psychiatrist. Results: Patients with MACS had a higher serum BDNF concentration than the NFAA (P = .001), while that of patients with NFAA was lower than the controls (P = .044). Linear regression analysis revealed BMI and morning cortisol after overnight 1 mg dexamethasone (DST) were mostly associated with BDNF (P < .05). No significant difference was found in MoCA scores between MACS and NFAA groups (P = .967), whereas those were lower than the control group (P = .004). When the cognitive subdomains were examined separately, MACS group performed higher memory score than NFAA (P = .045), but lower language scores than both the NFAA (P = .024) and control groups (P < .001). In the whole group, BDNF concentration was positively correlated with memory score (r = 0.337, P = .002), whereas DST was negatively correlated with language score (r = -0.355, P = .008). Conclusion: Low-grade hypercortisolism is associated with elevated BDNF concentrations, which may be a protective factor for memory function in patients with MACS relative to those with NFAA. Competing Interests: Conflict of interest: None declared. (© The Author(s) 2024. Published by Oxford University Press on behalf of European Society of Endocrinology.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu