Alternative activation of mast cells by CD4+ T helper cells.

Autor:	Leveque E; Institut National de la Santé et de la Recherche Médicale, Unité Mixte de Recherche U1037, Centre de Recherche en Cancérologie de Toulouse, 2 Avenue H. Curien, F-31037, France.; Université Toulouse III - Paul Sabatier, 118 route de Narbone, Toulouse F-31062, France., Battut L; Université Toulouse III - Paul Sabatier, 118 route de Narbone, Toulouse F-31062, France.; Institut National de la Santé et de la Recherche Médicale, U1220, Institut de Recherche en Santé Digestive, Institut National de la Recherche Agronomique, Institut National Polytechnique de Toulouse-École Nationale Vétérinaire de Toulouse, CHU Purpan place du Dr Baylac CS 60039, Toulouse F-31024, France., Petitfils C; Université Toulouse III - Paul Sabatier, 118 route de Narbone, Toulouse F-31062, France.; Institut National de la Santé et de la Recherche Médicale, U1220, Institut de Recherche en Santé Digestive, Institut National de la Recherche Agronomique, Institut National Polytechnique de Toulouse-École Nationale Vétérinaire de Toulouse, CHU Purpan place du Dr Baylac CS 60039, Toulouse F-31024, France., Valitutti S; Institut National de la Santé et de la Recherche Médicale, Unité Mixte de Recherche U1037, Centre de Recherche en Cancérologie de Toulouse, 2 Avenue H. Curien, F-31037, France.; Université Toulouse III - Paul Sabatier, 118 route de Narbone, Toulouse F-31062, France.; Department of Pathology, Institut Universitaire du Cancer-Oncopole de Toulouse, Centre Hospitalier Universitaire de Toulouse, 1 avenue Irène Joliot-Curie, Toulouse F-31059, France., Cenac N; Université Toulouse III - Paul Sabatier, 118 route de Narbone, Toulouse F-31062, France.; Institut National de la Santé et de la Recherche Médicale, U1220, Institut de Recherche en Santé Digestive, Institut National de la Recherche Agronomique, Institut National Polytechnique de Toulouse-École Nationale Vétérinaire de Toulouse, CHU Purpan place du Dr Baylac CS 60039, Toulouse F-31024, France., Dietrich G; Université Toulouse III - Paul Sabatier, 118 route de Narbone, Toulouse F-31062, France.; Institut National de la Santé et de la Recherche Médicale, U1220, Institut de Recherche en Santé Digestive, Institut National de la Recherche Agronomique, Institut National Polytechnique de Toulouse-École Nationale Vétérinaire de Toulouse, CHU Purpan place du Dr Baylac CS 60039, Toulouse F-31024, France., Espinosa E; Université Toulouse III - Paul Sabatier, 118 route de Narbone, Toulouse F-31062, France.; Institut National de la Santé et de la Recherche Médicale, U1220, Institut de Recherche en Santé Digestive, Institut National de la Recherche Agronomique, Institut National Polytechnique de Toulouse-École Nationale Vétérinaire de Toulouse, CHU Purpan place du Dr Baylac CS 60039, Toulouse F-31024, France.
Jazyk:	angličtina
Zdroj:	Journal of leukocyte biology [J Leukoc Biol] 2024 Nov 04; Vol. 116 (5), pp. 1127-1141.
DOI:	10.1093/jleuko/qiae139
Abstrakt:	Effector CD4+ T (Teff) lymphocytes infiltrate sites of inflammation and orchestrate the immune response by instructing local leukocytes. Mast cells (MCs) are tissue sentinel cells strategically located near blood vessels and T cell-rich areas. MC/Teff cell interactions shape Teff cell responses, but in turn, Teff cell action on MCs is still poorly understood. Here, we analyzed the human MC/Teff cell interplay through both the application of RNA sequencing and functional assays. We showed that activated Teff cells induce a specific transcriptomic program in MCs including production of both inflammatory cytokines and chemokines, prostaglandin, and a FcεRI-dependent degranulation facilitation, thereby driving them toward an inflammatory phenotype. Moreover, Teff cells induce in MCs the capacity to interact with CD4+ T cells through a wide range of dedicated soluble and membrane ligands and to play the role of antigen-presenting cells. Competing Interests: Conflict of interest statement. None declared. (© The Author(s) 2024. Published by Oxford University Press on behalf of Society for Leukocyte Biology. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com.)
Databáze:	MEDLINE
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