Infantile Disseminated Bacille Calmette-Guérin Disease with Hemophagocytosis and Mimicking Juvenile Myelomonocytic Leukemia: A Case Report with Concise Literature Review.

Autor: Godkhindi VM; Department of Pathology, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, India., Gupta N; Department of Infectious Diseases, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, India., Bhat KV; Division of Paediatric Haematology and Oncology, Manipal Comprehensive Cancer Care Centre, Manipal Academy of Higher Education, Manipal, Karnataka, India., Venkatagiri AM; Division of Paediatric Haematology and Oncology, Manipal Comprehensive Cancer Care Centre, Manipal Academy of Higher Education, Manipal, Karnataka, India.
Jazyk: angličtina
Zdroj: International journal of mycobacteriology [Int J Mycobacteriol] 2024 Apr 01; Vol. 13 (2), pp. 213-217. Date of Electronic Publication: 2024 Jun 15.
DOI: 10.4103/ijmy.ijmy_48_24
Abstrakt: Bacille Calmette-Guérin (BCG) is a live-attenuated vaccine routinely administered to newborns to prevent severe forms of tuberculosis (TB) in TB-endemic countries. Disseminated BCG vaccine disease is a classic feature of children with human immunodeficiency virus (HIV) or primary immunodeficiency disorders (PIDs) and is associated with high mortality. We report a case of a 6-month-old infant with disseminated BCG disease and hemophagocytic lymphohistiocytosis mimicking juvenile myelomonocytic leukemia with no demonstrable features of HIV or PID even after extensive laboratory work-up and succumbed to progressive disease. Disseminated BCG disease is a rare and potentially fatal complication of BCG vaccine, and prompt immunological evaluation complemented by initiation of 4-drug antitubercular therapy and definitive treatment with antiretroviral therapy or hematopoietic stem cell transplant is warranted.
(Copyright © 2024 Copyright: © 2024 International Journal of Mycobacteriology.)
Databáze: MEDLINE
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