Successful Fertilization in a Case of Globozoospermia Through Assisted Oocyte Activation With Calcium Ionophores: A Case Report.

Autor:	Thapa P; Clinical Embryology, Datta Meghe Medical College, Datta Meghe Institute of Higher Education and Research (DU), Nagpur, IND., Bawaskar PA; Clinical Embryology, Datta Meghe Medical College, Datta Meghe Institute of Higher Education and Research (DU), Nagpur, IND., Badge A; Microbiology, Datta Meghe Medical College, Datta Meghe Institute of Higher Education and Research (DU), Nagpur, IND., Pareek C; Clinical Embryology, Datta Meghe Medical College, Datta Meghe Institute of Higher Education and Research (DU), Nagpur, IND., Kalbande A; Obstetrics and Gynaecology, School of Allied Health Sciences, Datta Meghe Institute of Higher Education and Research (DU), Wardha, IND.
Jazyk:	angličtina
Zdroj:	Cureus [Cureus] 2024 May 25; Vol. 16 (5), pp. e61065. Date of Electronic Publication: 2024 May 25 (Print Publication: 2024).
DOI:	10.7759/cureus.61065
Abstrakt:	Globozoospermia is a rare sperm morphological abnormality characterized by a lack of acrosomes and post-acrosomal sheaths, defects in the cytoskeleton around the nucleus, and separated nuclear membranes. In this case, the study outlines the treatment of a 32-year-old male patient diagnosed with globozoospermia. The couple, facing primary infertility for seven years, had already undergone unsuccessful assisted reproductive technology treatments, such as two intrauterine inseminations and one in vitro fertilization. They opted for intracytoplasmic sperm injection (ICSI) with assisted oocyte activation (AOA) using a calcium (Ca) ionophore. The semen analysis showed globozoospermia, which indicated that ICSI was required for fertilization. Post-fertilization, embryo quality was assessed; three were in cleavage-stage embryos, and two grade 4AA and 3AA blastocysts and the rest were arrested at 2 pronuclear (2PN) stages, revealing successful embryo development. This case report implies that using AOA with Ca ionophores enhanced the fertilization outcomes and could be a helpful intervention strategy for patients with globozoospermia. Competing Interests: The authors have declared that no competing interests exist. (Copyright © 2024, Thapa et al.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu