Adolescents With Breakthrough COVID-19 Infections Requiring Hospitalization: A Multicenter Retrospective Study.

Autor:	Şahbudak Bal Z; Department of Pediatric Infectious Diseases, Ege University Faculty of Medicine, İzmir, TUR., Yildirim Arslan S; Department of Pediatric Infectious Diseases, Ege University Faculty of Medicine, İzmir, TUR., Guner Ozenen G; Department of Pediatric Infectious Diseases, University of Health Sciences Dr. Behcet Uz Child Disease and Pediatric Surgery Training and Research Hospital, İzmir, TUR., Şener Okur D; Department of Pediatric Infectious Diseases, Pamukkale University, Denizli, TUR., Kılıçaslan Ö; Department of Pediatric Infectious Diseases, Prof. Dr. Cemil Taşçıoğlu City Hospital, İstanbul, TUR., Demirbuga A; Department of Pediatric Infectious Diseases, Istanbul University School of Medicine, İstanbul, TUR., Afat Turgut E; Department of Pediatric Infectious Diseases, Adana City Training Hospital, Adana, TUR., Dalgıc N; Department of Pediatrics, Division of Infectious Diseases, Sisli Hamidiye Etfal Training and Research Hospital, İstanbul, TUR., Belet N; Department of Pediatrics, Division of Infectious Diseases, Medical School of Dokuz Eylül University, İzmir, TUR., İnceli HB; Department of Pediatrics, Division of Infectious Diseases, Medical School of Ankara University, Ankara, TUR., Elvan-Tuz A; Department of Pediatrics, Division of Infectious Diseases, Health Sciences University Tepecik Training and Research Hospital, İzmir, TUR., Tural Kara T; Department of Pediatrics, Division of Infectious Diseases, Medical School of Akdeniz University, Antalya, TUR., Bulbul B; Department of Pediatrics, Division of Infectious Diseases, Medical School of Uludag University, Bursa, TUR., Demirdag T; Department of Pediatric Infectious Diseases, Gazi University, Ankara, TUR., Çakıcı Ö; Department of Pediatrics and Child Health, Division of Pediatric Infectious Diseases, Section of Internal Medical Sciences, Faculty of Medicine, Kocaeli University, Izmit, TUR., Bal A; Department of Pediatric Emergency, Manisa Celal Bayar University Faculty of Medicine, Manisa, TUR., Ergun D; Department of Pediatrics, Division of Infectious Diseases, University of Health Sciences Dr. Behcet Uz Child Disease and Pediatric Surgery Training and Research Hospital, İzmir, TUR., Altug U; Department of Pediatrics, Medical School of Pamukkale University, Denizli, TUR., Arslan A; Department of Pediatrics, Division of Infectious Diseases, Medical School of Ege University, İzmir, TUR., Kizmaz İsancli D; Department of Pediatrics, Division of Infectious Diseases, Prof. Dr. Cemil Taşçıoğlu City Hospital, İstanbul, TUR., Hancerli Torun S; Department of Pediatrics, Division of Infectious Diseases, Medical School of Istanbul University, İstanbul, TUR., Çelik Ü; Department of Pediatrics, Division of Infectious Diseases, Adana City Hospital, Adana, TUR., Yasar B; Department of Pediatrics, Division of Infectious Diseases, Sisli Hamidiye Etfal Training and Research Hospital, İstanbul, TUR., Erbas İC; Department of Pediatrics, Division of Infectious Diseases, Medical School of Dokuz Eylül University, İzmir, TUR., Karadag Oncel E; Department of Pediatrics, Division of Infectious Diseases, Health Sciences University Tepecik Training and Research Hospital, İzmir, TUR., Akbas A; Department of Pediatrics, Medical School of Akdeniz University, Antalya, TUR., Gudeloglu E; Department of Pediatrics, Division of Infectious Diseases, Medical School of Gazi University, Ankara, TUR., Şen S; Department of Pediatrics, Division of Infectious Diseases, Manisa Celal Bayar University, Manisa, TUR., Kacar P; Department of Pediatrics, Division of Infectious Diseases, University of Health Sciences Dr. Behcet Uz Child Disease and Pediatric Surgery Training and Research Hospital, İzmir, TUR., Dede E; Department of Pediatrics, Division of Infectious Diseases, Medical School of Istanbul University, İstanbul, TUR., Petmezci E; Department of Pediatrics, Division of Intensive Care Unit, Sisli Hamidiye Etfal Training and Research Hospital, İstanbul, TUR., Aksoy FD; Department of Pediatrics, Medical School of Uludag University, Bursa, TUR., Karbuz A; Department of Pediatric Infectious Diseases, Prof. Dr. Cemil Taşçıoğlu City Hospital, İstanbul, TUR., Öncel S; Department of Pediatrics and Child Health, Division of Pediatric Infectious Diseases, Section of Internal Medical Sciences, Faculty of Medicine, Kocaeli University, Izmit, TUR., Tezer H; Department of Pediatrics, Division of Infectious Diseases, Medical School of Gazi University, Ankara, TUR., Devrim İ; Department of Pediatrics, Division of Infectious Diseases, University of Health Sciences Dr. Behcet Uz Child Disease and Pediatric Surgery Training and Research Hospital, İzmir, TUR., Ciftci E; Department of Pediatrics, Division of Infectious Diseases, Medical School of Ankara University, Ankara, TUR., Hacimustafaoglu M; Department of Pediatric Infectious Diseases, Uludag University Medical Faculty, Bursa, TUR., Kurugol Z; Department of Pediatrics, Division of Infectious Diseases, Medical School of Ege University, İzmir, TUR.
Jazyk:	angličtina
Zdroj:	Cureus [Cureus] 2024 May 23; Vol. 16 (5), pp. e60940. Date of Electronic Publication: 2024 May 23 (Print Publication: 2024).
DOI:	10.7759/cureus.60940
Abstrakt:	Background Vaccines have the most important role in the battle against the COVID-19 pandemic. With the widespread use of vaccines, COVID-19 has remarkably declined. Adolescents were vaccinated after approvals for this age group, which was later than adults, and a nationwide vaccination program was implemented in August 2021 in Turkey for adolescents ≥12 years of age. Therefore, we aimed to determine the effects of the COVID-19 nationwide adolescent vaccination program on adolescent hospitalizations due to COVID-19 and multisystem inflammatory syndrome in children (MIS-C) by comparing two periods, including the vaccination period (VP) and the pre-VP (PVP). The second aim of this study is to compare the clinical features and disease severity of vaccine-breakthrough COVID-19 hospitalizations with unvaccinated individuals in the VP. Methods A retrospective multicenter study was conducted to determine and compare the number of hospitalizations due to COVID-19 and MIS-C between the VP (September 1, 2021, to August 31, 2022) and PVP (September 1, 2020, to August 31, 2021). We also compared the characteristics, risk factors, and outcomes of breakthrough infections of adolescents aged 12-18, which required hospitalization with the same age group of unvaccinated hospitalized individuals during the VP. Results During the study period, 3967 children (0-18 years) were hospitalized in the PVP and 5143 (0-18 years) in the VP. Of them, 35.4% were adolescents (12-18 years) in the PVP, and this rate was 18.6% in the VP; relative risk was 0.6467 (95% confidence interval [CI]: 0.6058-0.6904; p < 0.001). Patients with breakthrough COVID-19 were older (201 vs. 175 months, p < 0.001) and less commonly hospitalized for COVID-19 (81.5% vs. 60.4%, p < 0.001, odds ratio [OR]: 0.347 [95% CI: 0.184-0.654]). The majority of these infections were asymptomatic and mild (32% vs.72.9%: p < 0.001, OR: 5.718 [95% CI: 2.920-11.200]), and PICU admission was less frequently required (p = 0.011, OR: 0.188 [95% CI: 0.045-0.793]). Most breakthrough COVID-19 infections occurred within three months after the last vaccine dose (54.2%). Conclusions This study demonstrated a significant decrease in adolescent hospitalizations due to COVID-19 and MIS-C after implementing COVID-19 vaccines in Turkey. Breakthrough cases were less severe and mostly occurred three months after the last dose. This study emphasizes the importance of COVID-19 vaccines and that parents' decisions may be changed, particularly those who hesitate to or refuse vaccination. Competing Interests: The authors have declared that no competing interests exist. (Copyright © 2024, Şahbudak Bal et al.)
Databáze:	MEDLINE
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