Sex, racial, and APOE -ε4 allele differences in longitudinal white matter microstructure in multiple cohorts of aging and Alzheimer's disease.

Autor:	Peterson A; Vanderbilt Memory and Alzheimer's Center, Vanderbilt University School of Medicine, Nashville, TN.; Department of Neurology, Vanderbilt University Medical Center, Nashville, TN., Sathe A; Vanderbilt Memory and Alzheimer's Center, Vanderbilt University School of Medicine, Nashville, TN., Zaras D; Vanderbilt Memory and Alzheimer's Center, Vanderbilt University School of Medicine, Nashville, TN., Yang Y; Vanderbilt Memory and Alzheimer's Center, Vanderbilt University School of Medicine, Nashville, TN., Durant A; Vanderbilt Memory and Alzheimer's Center, Vanderbilt University School of Medicine, Nashville, TN., Deters KD; Department of Integrative Biology and Physiology, University of California, Los Angeles., Shashikumar N; Vanderbilt Memory and Alzheimer's Center, Vanderbilt University School of Medicine, Nashville, TN., Pechman KR; Vanderbilt Memory and Alzheimer's Center, Vanderbilt University School of Medicine, Nashville, TN., Kim ME; Department of Computer Science, Vanderbilt University, Nashville, TN., Gao C; Department of Electrical and Computer Engineering, Vanderbilt University, Nashville, TN., Khairi NM; Department of Electrical and Computer Engineering, Vanderbilt University, Nashville, TN., Li Z; Department of Electrical and Computer Engineering, Vanderbilt University, Nashville, TN., Yao T; Department of Computer Science, Vanderbilt University, Nashville, TN., Huo Y; Department of Computer Science, Vanderbilt University, Nashville, TN.; Department of Electrical and Computer Engineering, Vanderbilt University, Nashville, TN., Dumitrescu L; Vanderbilt Memory and Alzheimer's Center, Vanderbilt University School of Medicine, Nashville, TN.; Department of Neurology, Vanderbilt University Medical Center, Nashville, TN.; Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN.; Vanderbilt Brain Institute, Vanderbilt University Medical Center, Nashville, TN., Gifford KA; Vanderbilt Memory and Alzheimer's Center, Vanderbilt University School of Medicine, Nashville, TN.; Department of Neurology, Vanderbilt University Medical Center, Nashville, TN., Wilson JE; Vanderbilt Memory and Alzheimer's Center, Vanderbilt University School of Medicine, Nashville, TN.; Center for Cognitive Medicine, Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, TN.; Veteran's Affairs, Geriatric Research, Education and Clinical Center, Tennessee Valley Healthcare System., Cambronero F; Vanderbilt Memory and Alzheimer's Center, Vanderbilt University School of Medicine, Nashville, TN., Risacher SL; Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN.; Indiana Alzheimer's Disease Research Center, Indiana University School of Medicine, Indianapolis, IN., Beason-Held LL; Laboratory for Behavioral Neuroscience, National Institute on Aging, National Institutes of Health, Baltimore, MD., An Y; Laboratory for Behavioral Neuroscience, National Institute on Aging, National Institutes of Health, Baltimore, MD., Arfanakis K; Department of Biomedical Engineering, Illinois Institute of Technology, Chicago, IL.; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL.; Department of Diagnostic Radiology, Rush University Medical Center, Chicago, IL., Erus G; Department of Radiology, University of Pennsylvania, Philadelphia, PA., Davatzikos C; Department of Radiology, University of Pennsylvania, Philadelphia, PA., Tosun D; Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA., Toga AW; Laboratory of Neuroimaging, USC Stevens Institute of Neuroimaging and Informatics, Keck School of Medicine, University of Southern California, Los Angeles, CA., Thompson PM; Imaging Genetics Center, Mark and Mary Stevens Institute for Neuroimaging and Informatics, Keck School of Medicine, University of Southern California, Marina del Rey, CA., Mormino EC; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA., Zhang P; Vanderbilt Memory and Alzheimer's Center, Vanderbilt University School of Medicine, Nashville, TN.; Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN., Schilling K; Department of Radiology & Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN2.; Vanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, TN., Albert M; Department of Neurology, Johns Hopkins School of Medicine Baltimore, MD., Kukull W; National Alzheimer's Coordinating Center, University of Washington, Seattle, WA., Biber SA; National Alzheimer's Coordinating Center, University of Washington, Seattle, WA., Landman BA; Department of Neurology, Vanderbilt University Medical Center, Nashville, TN.; Department of Computer Science, Vanderbilt University, Nashville, TN.; Department of Electrical and Computer Engineering, Vanderbilt University, Nashville, TN.; Vanderbilt Brain Institute, Vanderbilt University Medical Center, Nashville, TN.; Department of Radiology & Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN2.; Vanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, TN.; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN., Johnson SC; Wisconsin Alzheimer's Disease Research Center, School of Medicine and Public Health, University of Wisconsin, Madison, WI.; Wisconsin Alzheimer's Institute, School of Medicine and Public Health, University of Wisconsin, Madison, WI., Schneider J; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL., Barnes LL; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL., Bennett DA; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL., Jefferson AL; Vanderbilt Memory and Alzheimer's Center, Vanderbilt University School of Medicine, Nashville, TN.; Department of Neurology, Vanderbilt University Medical Center, Nashville, TN.; Department of Computer Science, Vanderbilt University, Nashville, TN., Resnick SM; Laboratory for Behavioral Neuroscience, National Institute on Aging, National Institutes of Health, Baltimore, MD., Saykin AJ; Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN.; Indiana Alzheimer's Disease Research Center, Indiana University School of Medicine, Indianapolis, IN., Hohman TJ; Vanderbilt Memory and Alzheimer's Center, Vanderbilt University School of Medicine, Nashville, TN.; Department of Neurology, Vanderbilt University Medical Center, Nashville, TN.; Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN.; Vanderbilt Brain Institute, Vanderbilt University Medical Center, Nashville, TN., Archer DB; Vanderbilt Memory and Alzheimer's Center, Vanderbilt University School of Medicine, Nashville, TN.; Department of Neurology, Vanderbilt University Medical Center, Nashville, TN.; Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN.; Vanderbilt Brain Institute, Vanderbilt University Medical Center, Nashville, TN.
Jazyk:	angličtina
Zdroj:	BioRxiv : the preprint server for biology [bioRxiv] 2024 Jun 12. Date of Electronic Publication: 2024 Jun 12.
DOI:	10.1101/2024.06.10.598357
Abstrakt:	Introduction: The effects of sex, race, and Apolipoprotein E ( APOE ) - Alzheimer's disease (AD) risk factors - on white matter integrity are not well characterized. Methods: Diffusion MRI data from nine well-established longitudinal cohorts of aging were free-water (FW)-corrected and harmonized. This dataset included 4,702 participants (age=73.06 ± 9.75) with 9,671 imaging sessions over time. FW and FW-corrected fractional anisotropy (FA FWcorr ) were used to assess differences in white matter microstructure by sex, race, and APOE -ε4 carrier status. Results: Sex differences in FA FWcorr in association and projection tracts, racial differences in FA FWcorr in projection tracts, and APOE -ε4 differences in FW limbic and occipital transcallosal tracts were most pronounced. Discussion: There are prominent differences in white matter microstructure by sex, race, and APOE -ε4 carrier status. This work adds to our understanding of disparities in AD. Additional work to understand the etiology of these differences is warranted. Competing Interests: SCJ has served on advisory boards for Enigma Biomedical and ALZPath in the past two years. AJS receives support from multiple NIH grants (P30 AG010133, P30 AG072976, R01 AG019771, R01 AG057739, U19 AG024904, R01 LM013463, R01 AG068193, T32 AG071444, U01 AG068057, U01 AG072177, U19 AG074879, and U24 AG074855). He has also received support from Avid Radiopharmaceuticals, a subsidiary of Eli Lilly (in kind contribution of PET tracer precursor) and participated in Scientific Advisory Boards (Bayer Oncology, Eisai, Novo Nordisk, and Siemens Medical Solutions USA, Inc) and an Observational Study Monitoring Board (MESA, NIH NHLBI), as well as External Advisory Committees for multiple NIA grants. He also serves as Editor-in-Chief of Brain Imaging and Behavior, a Springer-Nature Journal.
Databáze:	MEDLINE
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