Deep brain stimulation induces white matter remodeling and functional changes to brain-wide networks.

Autor:	Fujimoto SH; Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai; New York, NY 10029, USA.; Lipschultz Center for Cognitive Neuroscience, Icahn School of Medicine at Mount Sinai; New York, NY 10029, USA., Fujimoto A; Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai; New York, NY 10029, USA.; Lipschultz Center for Cognitive Neuroscience, Icahn School of Medicine at Mount Sinai; New York, NY 10029, USA., Elorette C; Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai; New York, NY 10029, USA.; Lipschultz Center for Cognitive Neuroscience, Icahn School of Medicine at Mount Sinai; New York, NY 10029, USA., Seltzer A; Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai; New York, NY 10029, USA.; Lipschultz Center for Cognitive Neuroscience, Icahn School of Medicine at Mount Sinai; New York, NY 10029, USA., Andraka E; Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai; New York, NY 10029, USA.; Lipschultz Center for Cognitive Neuroscience, Icahn School of Medicine at Mount Sinai; New York, NY 10029, USA., Verma G; Nash Family Center for Advanced Circuit Therapeutics, Mount Sinai West Hospital; New York, NY 10019, USA.; BioMedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai; New York, NY 10029, USA., Janssen WG; Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai; New York, NY 10029, USA., Fleysher L; BioMedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai; New York, NY 10029, USA., Folloni D; Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai; New York, NY 10029, USA.; Lipschultz Center for Cognitive Neuroscience, Icahn School of Medicine at Mount Sinai; New York, NY 10029, USA., Choi KS; Nash Family Center for Advanced Circuit Therapeutics, Mount Sinai West Hospital; New York, NY 10019, USA.; BioMedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai; New York, NY 10029, USA., Russ BE; Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai; New York, NY 10029, USA.; Center for Biomedical Imaging and Neuromodulation, Nathan Kline Institute; Orangeburg, NY 10962, USA.; Department of Psychiatry, New York University at Langone; New York, NY 10016, USA., Mayberg HS; Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai; New York, NY 10029, USA.; Nash Family Center for Advanced Circuit Therapeutics, Mount Sinai West Hospital; New York, NY 10019, USA., Rudebeck PH; Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai; New York, NY 10029, USA.; Lipschultz Center for Cognitive Neuroscience, Icahn School of Medicine at Mount Sinai; New York, NY 10029, USA.
Jazyk:	angličtina
Zdroj:	BioRxiv : the preprint server for biology [bioRxiv] 2024 Jun 14. Date of Electronic Publication: 2024 Jun 14.
DOI:	10.1101/2024.06.13.598710
Abstrakt:	Deep brain stimulation (DBS) is an emerging therapeutic option for treatment resistant neurological and psychiatric disorders, most notably depression. Despite this, little is known about the anatomical and functional mechanisms that underlie this therapy. Here we targeted stimulation to the white matter adjacent to the subcallosal anterior cingulate cortex (SCC-DBS) in macaques, modeling the location in the brain proven effective for depression. We demonstrate that SCC-DBS has a selective effect on white matter macro- and micro-structure in the cingulum bundle distant to where stimulation was delivered. SCC-DBS also decreased functional connectivity between subcallosal and posterior cingulate cortex, two areas linked by the cingulum bundle and implicated in depression. Our data reveal that white matter remodeling as well as functional effects contribute to DBS's therapeutic efficacy. Competing Interests: Conflict of interest: HSM and KC receive consulting fees from Abbott Neuromodulation. The other authors declare no competing financial interest. SHF, AF, CE, AS, EA, GV, WGJ, LF, DF, BER and PER have no competing interests.
Databáze:	MEDLINE
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