Late-onset temporal lobe epilepsy: insights from brain atrophy and Alzheimer's disease biomarkers.

Autor:	Ballerini A; Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, 41125, Modena, Italy., Biagioli N; Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, 41125, Modena, Italy., Carbone C; Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, 41125, Modena, Italy., Chiari A; Neurology Unit, OCB Hospital, Neuroscience Department, AOU Modena, 41126, Modena, Italy., Tondelli M; Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, 41125, Modena, Italy.; Neurology Unit, OCB Hospital, Neuroscience Department, AOU Modena, 41126, Modena, Italy., Vinceti G; Neurology Unit, OCB Hospital, Neuroscience Department, AOU Modena, 41126, Modena, Italy., Bedin R; Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, 41125, Modena, Italy., Malagoli M; Neuroradiology Unit, OCB Hospital, Neuroscience Department, AOU Modena, 41126, Modena, Italy., Genovese M; Neuroradiology Unit, OCB Hospital, Neuroscience Department, AOU Modena, 41126, Modena, Italy., Scolastico S; Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, 41125, Modena, Italy., Giovannini G; Neurophysiology Unit and Epilepsy Centre, Neuroscience Department, AOU Modena, 41126, Modena, Italy., Pugnaghi M; Neurophysiology Unit and Epilepsy Centre, Neuroscience Department, AOU Modena, 41126, Modena, Italy., Orlandi N; Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, 41125, Modena, Italy.; Neurophysiology Unit and Epilepsy Centre, Neuroscience Department, AOU Modena, 41126, Modena, Italy., Lemieux L; Department of Clinical and Experimental Epilepsy, UCL Institute of Neurology, Queen Square, London WC1N 3BG, UK., Meletti S; Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, 41125, Modena, Italy.; Neurophysiology Unit and Epilepsy Centre, Neuroscience Department, AOU Modena, 41126, Modena, Italy., Zamboni G; Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, 41125, Modena, Italy.; Neurology Unit, OCB Hospital, Neuroscience Department, AOU Modena, 41126, Modena, Italy., Vaudano AE; Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, 41125, Modena, Italy.; Neurophysiology Unit and Epilepsy Centre, Neuroscience Department, AOU Modena, 41126, Modena, Italy.
Jazyk:	angličtina
Zdroj:	Brain : a journal of neurology [Brain] 2024 Jun 25. Date of Electronic Publication: 2024 Jun 25.
DOI:	10.1093/brain/awae207
Abstrakt:	Considering the growing age of the world population, the incidence of epilepsy in older adults is expected to increase significantly. It has been suggested that late-onset temporal lobe epilepsy (LO-TLE) may be neurodegenerative in origin and overlap with Alzheimer's Disease (AD). Herein, we aimed to characterize the pattern of cortical atrophy and cerebrospinal fluid (CSF) biomarkers of AD (total and phosphorylated tau, and β-amyloid) in a selected population of LO-TLE of unknown origin. We prospectively enrolled individuals with temporal lobe epilepsy onset after the age of 50 and no cognitive impairment. They underwent a structural MRI scan and CSF biomarkers measurement. Imaging and biomarkers data were compared to three retrospectively collected groups: (i) age-sex-matched healthy controls, (ii) patients with Mild Cognitive Impairment (MCI) and abnormal CSF AD biomarkers (MCI-AD), and (iii) patients with MCI and normal CSF AD biomarkers (MCI-noAD). From a pool of 52 patients, twenty consecutive eligible LO-TLE patients with a mean disease duration of 1.8 years were recruited. As control populations, 25 patients with MCI-AD, 25 patients with MCI-noAD, and 25 healthy controls were enrolled. CSF biomarkers returned normal values in LO-TLE, significantly different from patients with MCI due to AD. There were no differences in cortico-subcortical atrophy between epilepsy patients and healthy controls, while patients with MCI demonstrated widespread injuries of cortico-subcortical structures. Individuals with a late-onset form of temporal lobe epilepsy, characterized by short disease duration and normal CSF β-amyloid and tau protein levels, showed patterns of cortical thickness and subcortical volumes not significantly different from healthy controls, but highly different from patients with MCI, either due to Alzheimer's Disease or not. (© The Author(s) 2024. Published by Oxford University Press on behalf of the Guarantors of Brain. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com.)
Databáze:	MEDLINE
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