Frequency of Delayed Puberty in Boys with Contemporary Management of Duchenne Muscular Dystrophy

Autor: McCarrison S; Royal Hospital for Children, Clinic of Paediatric Endocrinology, Glasgow, United Kingdom, Denker M; Royal Hospital for Children, Clinic of Paediatric Endocrinology, Glasgow, United Kingdom, Dunne J; Royal Hospital for Children, Clinic of Paediatric Neurology, Glasgow, United Kingdom, Horrocks I; Royal Hospital for Children, Clinic of Paediatric Neurology, Glasgow, United Kingdom, McNeilly J; Queen Elizabeth University Hospital, Department of Biochemistry, Glasgow, United Kingdom, Joseph S; Royal Hospital for Children, Clinic of Paediatric Neurology, Glasgow, United Kingdom, Wong SC; Royal Hospital for Children, Clinic of Paediatric Endocrinology, Glasgow, United Kingdom; University of Glasgow, Department of Human Nutrition, Glasgow, United Kingdom
Jazyk: angličtina
Zdroj: Journal of clinical research in pediatric endocrinology [J Clin Res Pediatr Endocrinol] 2024 Dec 04; Vol. 16 (4), pp. 458-465. Date of Electronic Publication: 2024 Jun 25.
DOI: 10.4274/jcrpe.galenos.2024.2024-2-18
Abstrakt: Objective: Delayed puberty is thought to be common in boys with Duchenne muscular dystrophy (DMD) treated with long term oral glucocorticoid. The aim of this study was to report the frequency of delayed puberty in DMD from examination by a paediatric endocrinologist alongside detailed endocrine investigations.
Methods: All boys with DMD aged at least 14 years in January 2022 known to the paediatric neuromuscular service (2016-2022) were included. Delayed puberty was defined based on testicular volume and genital staging in comparison to a published puberty nomogram.
Results: Twenty-four out of 37 boys (65%) had evidence of delayed puberty and 23/24 (96%) were on glucocorticoid therapy, all of whom were on daily glucocorticoid. However, 7/13 (54%) with normal timing of puberty were on glucocorticoid; 2/7 (29%) were on the intermittent regimen. Of those who were on daily glucocorticoid therapy at the time of assessment of puberty, 23/28 (82%) had evidence of delayed puberty. In boys with delayed puberty, endocrine investigations showed low luteinizing hormone with undetectable testosterone levels, a pre-pubertal response with lutenizing hormone releasing hormone test and sub-optimal testosterone levels with prolonged human chorionic gonadotropin stimulation.
Conclusion: The frequency of delayed puberty in boys with DMD was 65%. Eighty-two percent of adolescent boys with DMD on daily glucocorticoid had evidence of delayed puberty. Biochemical investigations point to functional central hypogonadism in these adolescents. Our data supports the routine monitoring of puberty in boys with DMD.
Competing Interests: Conflict of interest: None declared.
(©Copyright 2024 by Turkish Society for Pediatric Endocrinology and Diabetes / The Journal of Clinical Research in Pediatric Endocrinology published by Galenos Publishing House.)
Databáze: MEDLINE
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