Resting-state functional connectivity correlates of brain structural aging in schizophrenia.

Autor: Panikratova YR; Mental Health Research Center, Moscow, Russia. panikratova@mail.ru., Tomyshev AS; Mental Health Research Center, Moscow, Russia., Abdullina EG; Mental Health Research Center, Moscow, Russia., Rodionov GI; Institute of Higher Nervous Activity and Neurophysiology of Russian Academy of Sciences, Moscow, Russia., Arkhipov AY; Institute of Higher Nervous Activity and Neurophysiology of Russian Academy of Sciences, Moscow, Russia., Tikhonov DV; Mental Health Research Center, Moscow, Russia., Bozhko OV; Mental Health Research Center, Moscow, Russia., Kaleda VG; Mental Health Research Center, Moscow, Russia., Strelets VB; Institute of Higher Nervous Activity and Neurophysiology of Russian Academy of Sciences, Moscow, Russia., Lebedeva IS; Mental Health Research Center, Moscow, Russia.
Jazyk: angličtina
Zdroj: European archives of psychiatry and clinical neuroscience [Eur Arch Psychiatry Clin Neurosci] 2024 Jun 25. Date of Electronic Publication: 2024 Jun 25.
DOI: 10.1007/s00406-024-01837-5
Abstrakt: A large body of research has shown that schizophrenia patients demonstrate increased brain structural aging. Although this process may be coupled with aberrant changes in intrinsic functional architecture of the brain, they remain understudied. We hypothesized that there are brain regions whose whole-brain functional connectivity at rest is differently associated with brain structural aging in schizophrenia patients compared to healthy controls. Eighty-four male schizophrenia patients and eighty-six male healthy controls underwent structural MRI and resting-state fMRI. The brain-predicted age difference (b-PAD) was a measure of brain structural aging. Resting-state fMRI was applied to obtain global correlation (GCOR) maps comprising voxelwise values of the strength and sign of functional connectivity of a given voxel with the rest of the brain. Schizophrenia patients had higher b-PAD compared to controls (mean between-group difference + 2.9 years). Greater b-PAD in schizophrenia patients, compared to controls, was associated with lower whole-brain functional connectivity of a region in frontal orbital cortex, inferior frontal gyrus, Heschl's Gyrus, plana temporale and polare, insula, and opercular cortices of the right hemisphere (rFTI). According to post hoc seed-based correlation analysis, decrease of functional connectivity with the posterior cingulate gyrus, left superior temporal cortices, as well as right angular gyrus/superior lateral occipital cortex has mainly driven the results. Lower functional connectivity of the rFTI was related to worse verbal working memory and language production. Our findings demonstrate that well-established frontotemporal functional abnormalities in schizophrenia are related to increased brain structural aging.
(© 2024. Springer-Verlag GmbH Germany, part of Springer Nature.)
Databáze: MEDLINE
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