Efferocytosis and Bone Dynamics.

Autor: Batoon L; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, 55905, USA. batoon.lena@mayo.edu., Hawse JR; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, 55905, USA., McCauley LK; Department of Periodontics and Oral Medicine, School of Dentistry, University of Michigan, Ann Arbor, MI, 48109-1078, USA.; Department of Pathology, Medical School, University of Michigan, Ann Arbor, MI, 48104, USA., Weivoda MM; Division of Hematology, Mayo Clinic, Rochester, MN, 55905, USA., Roca H; Department of Periodontics and Oral Medicine, School of Dentistry, University of Michigan, Ann Arbor, MI, 48109-1078, USA. rocach@umich.edu.
Jazyk: angličtina
Zdroj: Current osteoporosis reports [Curr Osteoporos Rep] 2024 Oct; Vol. 22 (5), pp. 471-482. Date of Electronic Publication: 2024 Jun 24.
DOI: 10.1007/s11914-024-00878-y
Abstrakt: Purpose of Review: This review summarizes the recently published scientific evidence regarding the role of efferocytosis in bone dynamics and skeletal health.
Recent Findings: Several types of efferocytes have been identified within the skeleton, with macrophages being the most extensively studied. Efferocytosis is not merely a 'clean-up' process vital for maintaining skeletal homeostasis; it also plays a crucial role in promoting resolution pathways and orchestrating bone dynamics, such as osteoblast-osteoclast coupling during bone remodeling. Impaired efferocytosis has been associated with aging-related bone loss and various skeletal pathologies, including osteoporosis, osteoarthritis, rheumatoid arthritis, and metastatic bone diseases. Accordingly, emerging evidence suggests that targeting efferocytic mechanisms has the potential to alleviate these conditions. While efferocytosis remains underexplored in the skeleton, recent discoveries have shed light on its pivotal role in bone dynamics, with important implications for skeletal health and pathology. However, there are several knowledge gaps and persisting technical limitations that must be addressed to fully unveil the contributions of efferocytosis in bone.
(© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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