Prevalence of Helicobacter pylori resistance to certain antibiotics at An-Najah University Hospital: a cross-sectional study.

Autor: Abdoh Q; Faculty of Medicine, An-Najah National University, Nablus, Palestine. Qusaygi@yahoo.com.; Division of Gastroenterology, An-Najah National University Hospital, Nablus, Palestine. Qusaygi@yahoo.com., Alnees M; Faculty of Medicine, An-Najah National University, Nablus, Palestine. a2011z2012z2013@gmail.com.; Global Clinical Scholars Research Training Program, Harvard Medical School Postgraduate Medical Education, Boston, USA. a2011z2012z2013@gmail.com.; Department of Medicine, Faculty of Medicine and Health Sciences, An-Najah National University, Nablus, Palestine. a2011z2012z2013@gmail.com., Kharraz L; Faculty of Medicine, An-Najah National University, Nablus, Palestine., Ayoub K; Faculty of Medicine, An-Najah National University, Nablus, Palestine.; Department of Internal Medicine, Specialized Araby Hospital, Nablus, Palestine., Darwish A; Faculty of Medicine, An-Najah National University, Nablus, Palestine., Awwad M; Faculty of Medicine, An-Najah National University, Nablus, Palestine., Najajra D; Faculty of Medicine, An-Najah National University, Nablus, Palestine., Khraim J; Faculty of Medicine, An-Najah National University, Nablus, Palestine., Awad W; Faculty of Medicine, An-Najah National University, Nablus, Palestine., Sbaih A; Faculty of Medicine, An-Najah National University, Nablus, Palestine., Turman S; Faculty of Medicine, An-Najah National University, Nablus, Palestine., Abu Hamdeh N; Faculty of Medicine, An-Najah National University, Nablus, Palestine.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2024 Jun 24; Vol. 14 (1), pp. 14542. Date of Electronic Publication: 2024 Jun 24.
DOI: 10.1038/s41598-024-63982-0
Abstrakt: Antibiotic resistance among bacteria is recognized as the primary factor contributing to the failure of treatment. In this research, our objective was to examine the prevalence of antibiotic resistance in H. pylori bacteria in Palestine. We enlisted 91 individuals suffering from dyspepsia, comprising 49 females and 42 males. These participants underwent esophagogastroduodenoscopy procedures with gastric biopsies. These biopsies were subsequently subjected to microbiological assessments and tested for their susceptibility to various antimicrobial drugs. Among the 91 patients, 38 (41.7%) exhibited the presence of H. pylori. Notably, Ciprofloxacin displayed the highest efficacy against H. pylori, followed by Levofloxacin, Moxifloxacin, and Amoxicillin, with resistance rates of 0%, 0%, 2.6%, and 18.4%, respectively. On the contrary, Metronidazole and Clarithromycin demonstrated the lowest effectiveness, with resistance percentages of 100% and 47.4%, respectively. The outcomes of this investigation emphasize that H. pylori strains within the Palestinian patient group exhibit substantial resistance to conventional first-line antibiotics like clarithromycin and metronidazole. However, alternative agents such as fluoroquinolones and amoxicillin remain efficacious choices. Consequently, we recommend favoring quinolone-based treatment regimens for H. pylori infections and adopting a more judicious approach to antibiotic usage among the Palestinian population.
(© 2024. The Author(s).)
Databáze: MEDLINE
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