Creation of a biological sensorimotor interface for bionic reconstruction.

Autor: Festin C; Clinical Laboratory for Bionic Extremity Reconstruction, Department of Plastic, Reconstructive and Aesthetic Surgery, Medical University of Vienna, Vienna, Austria.; Center for Biomedical Research, Medical University of Vienna, Vienna, Austria., Ortmayr J; Clinical Laboratory for Bionic Extremity Reconstruction, Department of Plastic, Reconstructive and Aesthetic Surgery, Medical University of Vienna, Vienna, Austria., Maierhofer U; Clinical Laboratory for Bionic Extremity Reconstruction, Department of Plastic, Reconstructive and Aesthetic Surgery, Medical University of Vienna, Vienna, Austria.; Center for Biomedical Research, Medical University of Vienna, Vienna, Austria., Tereshenko V; Clinical Laboratory for Bionic Extremity Reconstruction, Department of Plastic, Reconstructive and Aesthetic Surgery, Medical University of Vienna, Vienna, Austria.; Center for Biomedical Research, Medical University of Vienna, Vienna, Austria.; Division of Plastic and Reconstructive Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Blumer R; Center for Anatomy and Cell Biology, Medical University of Vienna, Vienna, Austria., Schmoll M; Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, Austria., Carrero-Rojas G; Center for Anatomy and Cell Biology, Medical University of Vienna, Vienna, Austria., Luft M; Clinical Laboratory for Bionic Extremity Reconstruction, Department of Plastic, Reconstructive and Aesthetic Surgery, Medical University of Vienna, Vienna, Austria.; Center for Biomedical Research, Medical University of Vienna, Vienna, Austria.; Department of Plastic, Aesthetic and Reconstructive Surgery, University Hospital St. Poelten, Karl Landsteiner University of Health Sciences, Krems, Austria., Laengle G; Clinical Laboratory for Bionic Extremity Reconstruction, Department of Plastic, Reconstructive and Aesthetic Surgery, Medical University of Vienna, Vienna, Austria.; Center for Biomedical Research, Medical University of Vienna, Vienna, Austria.; Department of Plastic, Reconstructive and Aesthetic Surgery, Medical University of Vienna, Vienna, Austria., Farina D; Department of Bioengineering, Imperial College London, London, United Kingdom., Bergmeister KD; Clinical Laboratory for Bionic Extremity Reconstruction, Department of Plastic, Reconstructive and Aesthetic Surgery, Medical University of Vienna, Vienna, Austria.; Department of Plastic, Aesthetic and Reconstructive Surgery, University Hospital St. Poelten, Karl Landsteiner University of Health Sciences, Krems, Austria., Aszmann OC; Clinical Laboratory for Bionic Extremity Reconstruction, Department of Plastic, Reconstructive and Aesthetic Surgery, Medical University of Vienna, Vienna, Austria. oskar.aszmann@meduniwien.ac.at.; Department of Plastic, Reconstructive and Aesthetic Surgery, Medical University of Vienna, Vienna, Austria. oskar.aszmann@meduniwien.ac.at.
Jazyk: angličtina
Zdroj: Nature communications [Nat Commun] 2024 Jun 24; Vol. 15 (1), pp. 5337. Date of Electronic Publication: 2024 Jun 24.
DOI: 10.1038/s41467-024-49580-8
Abstrakt: Neuromuscular control of bionic arms has constantly improved over the past years, however, restoration of sensation remains elusive. Previous approaches to reestablish sensory feedback include tactile, electrical, and peripheral nerve stimulation, however, they cannot recreate natural, intuitive sensations. Here, we establish an experimental biological sensorimotor interface and demonstrate its potential use in neuroprosthetics. We transfer a mixed nerve to a skeletal muscle combined with glabrous dermal skin transplantation, thus forming a bi-directional communication unit in a rat model. Morphological analyses indicate reinnervation of the skin, mechanoreceptors, NMJs, and muscle spindles. Furthermore, sequential retrograde labeling reveals specific sensory reinnervation at the level of the dorsal root ganglia. Electrophysiological recordings show reproducible afferent signals upon tactile stimulation and tendon manipulation. The results demonstrate the possibility of surgically creating an interface for both decoding efferent motor control, as well as encoding afferent tactile and proprioceptive feedback, and may indicate the way forward regarding clinical translation of biological communication pathways for neuroprosthetic applications.
(© 2024. The Author(s).)
Databáze: MEDLINE
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