Safety of contrast-enhanced ultrasound using microbubbles in human pregnancy: A scoping review.

Autor:	Dassen S; Obstetrics and Gynacology, Maxima Medical Centre, Veldhoven, Netherlands., Monen L; Obstetrics and Gynacology, Maxima Medical Centre, Veldhoven, Netherlands., Oei G; Fundamental Perinatology, Technische Universiteit Eindhoven, Eindhoven, Netherlands., Mischi M; Electrical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands., van Laar J; Obstetrics and Gynacology, Maxima Medical Centre, Veldhoven, Netherlands.
Jazyk:	angličtina
Zdroj:	Ultraschall in der Medizin (Stuttgart, Germany : 1980) [Ultraschall Med] 2024 Jun 24. Date of Electronic Publication: 2024 Jun 24.
DOI:	10.1055/a-2351-0747
Abstrakt:	Introduction - Successful placentation is crucial for fetal development and maintaining a healthy pregnancy. Placental insufficiency can cause a variety of obstetric complications. Despite the many efforts to enhance diagnosing placental insufficiency, no imaging technique has proven satisfactory. A promising imaging technique is contrast-enhanced ultrasound (CEUS) using microbubbles which is proven capable of (micro)vascular imaging. Its use for placental vascularization assessment in human pregnancies remains constrained by limited evidence and safety concerns. This scoping review aims to demonstrate the safety of CEUS used in human pregnancy in the published literature to date. Material and methods - a systematic search using PubMed, Medline, Embase, and Cochrane databases was performed. All studies where contrast-enhanced ultrasound was used in pregnant humans were included. Studies, where there was a planned termination of pregnancy, were excluded. To assess the safety of CEUS during pregnancy, relevant outcomes were divided into the following three categories; fetal outcome, maternal outcome, and pregnancy and neonatal outcomes. Results - A total of 13 articles were included, in which 256 women received CEUS during pregnancy. No clinically significant maternal or fetal adverse events or negative pregnancy or neonatal outcomes associated with CEUS were described. Conclusions - Based on our findings, we consider expanding the knowledge of this promising diagnostic technique in the future, larger clinical studies safe and relevant. Competing Interests: The authors declare that they have no conflict of interest. (The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu