Multitargeted polypharmacotherapy for cancer treatment. theoretical concepts and proposals.

Autor:	Duenas-Gonzalez A; Departamento de Medicina Genómica y Toxicología Ambiental, Instituto de Investigaciones Biomédicas UNAM, Mexico City, Mexico.; Subdireccion de Investigación Básica, Instituto Nacional de Cancerología, Mexico City, Mexico., Gonzalez-Fierro A; Subdireccion de Investigación Básica, Instituto Nacional de Cancerología, Mexico City, Mexico., Bornstein-Quevedo L; Immunohistochemistry and Molecular Biology Laboratory, InmunoQ, Mexico City, Mexico., Gutierrez-Delgado F; Centro de Estudios y Prevención del Cancer Tuxtla Gutiérrez, Chiapas, México; Latin American School of Oncology (ELO), México City, Mexico., Kast RE; Head of Faculty, Brain Study, IIAIG Study Center, Burlington, VT, USA., Chavez-Blanco A; Subdireccion de Investigación Básica, Instituto Nacional de Cancerología, Mexico City, Mexico., Dominguez-Gomez G; Subdireccion de Investigación Básica, Instituto Nacional de Cancerología, Mexico City, Mexico., Candelaria M; Departamento de Hematología, Instituto Nacional de Cancerología, Mexico City, Mexico., Romo-Pérez A; Instituto de Química, Universidad Nacional Autónoma de México, Mexico City, Mexico., Correa-Basurto J; Laboratorio de Diseño y Desarrollo de Nuevos Fármacos e Innovación Biotecnológica, SEPI-ESM, Instituto Politécnico Nacional, México, Mexico City, Mexico., Lizano M; Departamento de Medicina Genómica y Toxicología Ambiental, Instituto de Investigaciones Biomédicas UNAM, Mexico City, Mexico.; Subdireccion de Investigación Básica, Instituto Nacional de Cancerología, Mexico City, Mexico., Perez-de la Cruz V; Neurobiochemistry and Behavior Laboratory, National Institute of Neurology and Neurosurgery 'Manuel Velasco Suárez', Mexico City, Mexico., Robles-Bañuelos B; Subdireccion de Investigación Básica, Instituto Nacional de Cancerología, Mexico City, Mexico., Nuñez-Corona D; Subdireccion de Investigación Básica, Instituto Nacional de Cancerología, Mexico City, Mexico., Martinez-Perez E; Subdireccion de Investigación Básica, Instituto Nacional de Cancerología, Mexico City, Mexico., Verastegui E; Departamento de Cuidados Paliativos, Division de Cirugia, Instituto Nacional de Cancerologia, Mexico City, Mexico.
Jazyk:	angličtina
Zdroj:	Expert review of anticancer therapy [Expert Rev Anticancer Ther] 2024 Aug; Vol. 24 (8), pp. 665-677. Date of Electronic Publication: 2024 Jul 08.
DOI:	10.1080/14737140.2024.2372336
Abstrakt:	Introduction: The pharmacological treatment of cancer has evolved from cytotoxic to molecular targeted therapy. The median survival gains of 124 drugs approved by the FDA from 2003 to 2021 is 2.8 months. Targeted therapy is based on the somatic mutation theory, which has some paradoxes and limitations. While efforts of targeted therapy must continue, we must study newer approaches that could advance therapy and affordability for patients. Areas Covered: This work briefly overviews how cancer therapy has evolved from cytotoxic chemotherapy to current molecular-targeted therapy. The limitations of the one-target, one-drug approach considering cancer as a robust system and the basis for multitargeting approach with polypharmacotherapy using repurposing drugs. Expert Opinion: Multitargeted polypharmacotherapy for cancer with repurposed drugs should be systematically investigated in preclinical and clinical studies. Remarkably, most of these proposed drugs already have a long history in the clinical setting, and their safety is known. In principle, the risk of their simultaneous administration should not be greater than that of a first-in-human phase I study as long as the protocol is developed with strict vigilance to detect early possible side effects from their potential interactions. Research on cancer therapy should go beyond the prevailing paradigm targeted therapy.
Databáze:	MEDLINE
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