Auditory cortical regions show resting-state functional connectivity with the default mode-like network in echolocating bats.

Autor:	Washington SD; Bio-Imaging Lab, Drie Eiken Campus, Department of Biomedical Sciences, University of Antwerp, Antwerp B-2610, Belgium.; McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA 02139.; Molecular Imaging Laboratory, Department of Radiology, Howard University, College of Medicine, Washington, DC 20060.; Department of Anatomy, Howard University, College of Medicine, Washington, DC 20060., Shattuck K; Department of Rehabilitation Medicine, Georgetown University Medical Center, Washington, DC 20057.; Department of Neurology, Georgetown University Medical Center, Washington, DC 20057., Steckel J; Department of Electronics-Information and Communication Technology, Cosys Lab, University of Antwerp, Antwerp B-2020, Belgium.; Flanders Make Strategic Research Center, Oude Diestersebaan 133, Lommel 3920, Belgium., Peremans H; Department of Engineering Management, University of Antwerp, Antwerp B-2000, Belgium., Jonckers E; Bio-Imaging Lab, Drie Eiken Campus, Department of Biomedical Sciences, University of Antwerp, Antwerp B-2610, Belgium.; µNeuro Research Centre for Excellence, Drie Eiken Campus, Department of Biomedical Sciences, University of Antwerp, Antwerp B-2610, Belgium., Hinz R; Bio-Imaging Lab, Drie Eiken Campus, Department of Biomedical Sciences, University of Antwerp, Antwerp B-2610, Belgium., Venneman T; Bio-Imaging Lab, Drie Eiken Campus, Department of Biomedical Sciences, University of Antwerp, Antwerp B-2610, Belgium., Van den Berg M; Bio-Imaging Lab, Drie Eiken Campus, Department of Biomedical Sciences, University of Antwerp, Antwerp B-2610, Belgium.; µNeuro Research Centre for Excellence, Drie Eiken Campus, Department of Biomedical Sciences, University of Antwerp, Antwerp B-2610, Belgium., Van Ruijssevelt L; Bio-Imaging Lab, Drie Eiken Campus, Department of Biomedical Sciences, University of Antwerp, Antwerp B-2610, Belgium., Verellen T; Department of Electronics-Information and Communication Technology, Cosys Lab, University of Antwerp, Antwerp B-2020, Belgium., Pritchett DL; Department of Biology, Howard University, College of Arts and Sciences, Washington, DC 20059., Scholliers J; Department of Biology, Drie Eiken Campus, University of Antwerp, Antwerp B-2610, Belgium.; Department of Biomedical Sciences, Drie Eiken Campus, University of Antwerp, Antwerp B-2610, Belgium., Liang S; Bio-Imaging Lab, Drie Eiken Campus, Department of Biomedical Sciences, University of Antwerp, Antwerp B-2610, Belgium., C Wang P; Molecular Imaging Laboratory, Department of Radiology, Howard University, College of Medicine, Washington, DC 20060.; Department of Physics, Fu Jen Catholic University, Taipei 24205, Taiwan., Verhoye M; Bio-Imaging Lab, Drie Eiken Campus, Department of Biomedical Sciences, University of Antwerp, Antwerp B-2610, Belgium.; µNeuro Research Centre for Excellence, Drie Eiken Campus, Department of Biomedical Sciences, University of Antwerp, Antwerp B-2610, Belgium., Esser KH; Institute of Zoology, University of Veterinary Medicine, Hannover 30559, Germany., Van der Linden A; Bio-Imaging Lab, Drie Eiken Campus, Department of Biomedical Sciences, University of Antwerp, Antwerp B-2610, Belgium.; µNeuro Research Centre for Excellence, Drie Eiken Campus, Department of Biomedical Sciences, University of Antwerp, Antwerp B-2610, Belgium., Keliris GA; Bio-Imaging Lab, Drie Eiken Campus, Department of Biomedical Sciences, University of Antwerp, Antwerp B-2610, Belgium.; Institute of Computer Science, Foundation for Research and Technology-Hellas, Heraklion, Crete, GR 700 13, Greece; and.; Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston 02115, MA.
Jazyk:	angličtina
Zdroj:	Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2024 Jul 02; Vol. 121 (27), pp. e2306029121. Date of Electronic Publication: 2024 Jun 24.
DOI:	10.1073/pnas.2306029121
Abstrakt:	Echolocating bats are among the most social and vocal of all mammals. These animals are ideal subjects for functional MRI (fMRI) studies of auditory social communication given their relatively hypertrophic limbic and auditory neural structures and their reduced ability to hear MRI gradient noise. Yet, no resting-state networks relevant to social cognition (e.g., default mode-like networks or DMLNs) have been identified in bats since there are few, if any, fMRI studies in the chiropteran order. Here, we acquired fMRI data at 7 Tesla from nine lightly anesthetized pale spear-nosed bats ( Phyllostomus discolor ). We applied independent components analysis (ICA) to reveal resting-state networks and measured neural activity elicited by noise ripples (on: 10 ms; off: 10 ms) that span this species' ultrasonic hearing range (20 to 130 kHz). Resting-state networks pervaded auditory, parietal, and occipital cortices, along with the hippocampus, cerebellum, basal ganglia, and auditory brainstem. Two midline networks formed an apparent DMLN. Additionally, we found four predominantly auditory/parietal cortical networks, of which two were left-lateralized and two right-lateralized. Regions within four auditory/parietal cortical networks are known to respond to social calls. Along with the auditory brainstem, regions within these four cortical networks responded to ultrasonic noise ripples. Iterative analyses revealed consistent, significant functional connectivity between the left, but not right, auditory/parietal cortical networks and DMLN nodes, especially the anterior-most cingulate cortex. Thus, a resting-state network implicated in social cognition displays more distributed functional connectivity across left, relative to right, hemispheric cortical substrates of audition and communication in this highly social and vocal species. Competing Interests: Competing interests statement:The authors declare no competing interest.
Databáze:	MEDLINE
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