Unravelling relationships between obesity, diabetes, and factors related to somatosensory functioning in knee osteoarthritis patients.

Autor: Meert L; Research Group MOVANT, Department of Rehabilitation Sciences and Physiotherapy (REVAKI), University of Antwerp, Wilrijk, Belgium. l.meert@maastrichtuniversity.nl.; Research School CAPHRI, Department of Rehabilitation Medicine, Maastricht University, Universiteitssingel 40, 6229 ER, Maastricht, The Netherlands. l.meert@maastrichtuniversity.nl.; Pain in Motion International Research Group (PiM), Brussels, Belgium. l.meert@maastrichtuniversity.nl., Vervullens S; Research Group MOVANT, Department of Rehabilitation Sciences and Physiotherapy (REVAKI), University of Antwerp, Wilrijk, Belgium.; Research School CAPHRI, Department of Rehabilitation Medicine, Maastricht University, Universiteitssingel 40, 6229 ER, Maastricht, The Netherlands.; Pain in Motion International Research Group (PiM), Brussels, Belgium., Heusdens CHW; Department of Orthopedics and Traumatology, University Hospital of Antwerp, Edegem, Belgium.; Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium., Smeets RJEM; Research School CAPHRI, Department of Rehabilitation Medicine, Maastricht University, Universiteitssingel 40, 6229 ER, Maastricht, The Netherlands.; Pain in Motion International Research Group (PiM), Brussels, Belgium.; CIR Clinics in Revalidatie, Eindhoven, The Netherlands., Meeus M; Research Group MOVANT, Department of Rehabilitation Sciences and Physiotherapy (REVAKI), University of Antwerp, Wilrijk, Belgium.; Pain in Motion International Research Group (PiM), Brussels, Belgium., Mertens MGCAM; Research Group MOVANT, Department of Rehabilitation Sciences and Physiotherapy (REVAKI), University of Antwerp, Wilrijk, Belgium.; Research School CAPHRI, Department of Rehabilitation Medicine, Maastricht University, Universiteitssingel 40, 6229 ER, Maastricht, The Netherlands.; Pain in Motion International Research Group (PiM), Brussels, Belgium.
Jazyk: angličtina
Zdroj: Clinical rheumatology [Clin Rheumatol] 2024 Aug; Vol. 43 (8), pp. 2637-2645. Date of Electronic Publication: 2024 Jun 24.
DOI: 10.1007/s10067-024-07022-2
Abstrakt: Objective: This study explores the association between obesity, diabetes, and somatosensory functioning in patients with knee osteoarthritis (OA), aiming to understand how metabolic conditions are related to pain mechanisms in this patient population. We hypothesized that higher body mass index (BMI), fat mass, and glycated hemoglobin levels (HbA1c) are associated with signs of altered somatosensory functioning.
Methods: A cross-sectional analysis was conducted as part of a larger multicentre prospective cohort study. Data were collected from patients awaiting total knee arthroplasty in Belgium and the Netherlands. Associations between BMI, fat mass, HbA1c, and various pain-related variables were examined employing Pearson and Spearman correlation analyses which were further analyzed with linear regression techniques.
Results: The study included 223 participants. Analysis revealed a significant although weak negative correlation between fat mass and pressure pain thresholds (PPT) at multiple locations, suggesting a link between higher fat mass and increased mechanical hyperalgesia. There were no significant correlations between BMI and pain-related outcomes. HbA1c levels showed very weak positive correlations with pain measures but did not withstand correction for multiple testing.
Conclusion: The findings indicate that fat mass may be closely associated with altered somatosensory functioning in patients with knee OA. However, no significant correlations were found between BMI or HbA1c levels and pain-related outcomes. Future research should focus on longitudinal studies to elucidate the causal relationships and further explore the impact of metabolic factors on pain mechanisms in this patient population. Key Points • The findings indicate that fat mass may be closely associated with altered somatosensory functioning in patients with knee OA.
(© 2024. The Author(s).)
Databáze: MEDLINE
Externí odkaz: