Distinctive sleep complaints and polysomnographic findings in antibody subgroups of autoimmune limbic encephalitis.

Autor: Küçükali Cİ; Department of Neuroscience, Aziz Sancar Institute of Experimental Medicine, Istanbul University, Istanbul, Türkiye., Yılmaz V; Department of Neuroscience, Aziz Sancar Institute of Experimental Medicine, Istanbul University, Istanbul, Türkiye., Karadeniz D; Division of Clinical Neurophysiology, Department of Neurology, Istanbul University-Cerrahpasa, Cerrahpasa Faculty of Medicine, Istanbul, Türkiye., Akyıldız UO; Department of Neurology, Adnan Menderes University Medical Faculty, Aydın, Türkiye., İlhan Algın D; Department of Neurology, Eskisehir Osmangazi University Medical Faculty, Eskisehir, Türkiye., Sarıtaş AŞ; Department of Neurology, Celal Bayar University Medical Faculty, Manisa, Türkiye., Kısabay Ak A; Department of Neurology, Celal Bayar University Medical Faculty, Manisa, Türkiye., Bican Demir A; Department of Neurology, Bursa Uludag University Medical Faculty, Bursa, Türkiye., Yılmaz H; Department of Neurology, Celal Bayar University Medical Faculty, Manisa, Türkiye., Domaç FM; Department of Neurology, Erenkoy Mental and Nervous Diseases Training and Research Hospital, University of Health Sciences, Istanbul, Türkiye., Elmalı AD; Department of Neurology, Ministry of Health Basaksehir Cam and Sakura City Hospital, Istanbul, Türkiye., Hoş ÜD; Department of Neurology, Ministry of Health Basaksehir Cam and Sakura City Hospital, Istanbul, Türkiye., Gözübatık-Çelik RG; Bakirkoy Prof. Dr. Mazhar Osman Training and Research Hospital for Psychiatric, Neurologic and Neurosurgical Diseases, University of Health Sciences, Istanbul, Türkiye., Kabeloğlu V; Bakirkoy Prof. Dr. Mazhar Osman Training and Research Hospital for Psychiatric, Neurologic and Neurosurgical Diseases, University of Health Sciences, Istanbul, Türkiye., Bilgin B; Department of Pediatrics, Kahramanmaras Sutcu Imam University Medical Faculty, Kahramanmaras, Türkiye., Tuncel Berktaş D; Department of Neurology, Kahramanmaras Sutcu Imam University Medical Faculty, Kahramanmaras, Türkiye., Türk BG; Division of Clinical Neurophysiology, Department of Neurology, Istanbul University-Cerrahpasa, Cerrahpasa Faculty of Medicine, Istanbul, Türkiye., Delil Ş; Division of Clinical Neurophysiology, Department of Neurology, Istanbul University-Cerrahpasa, Cerrahpasa Faculty of Medicine, Istanbul, Türkiye., Dilber C; Department of Pediatrics, Kahramanmaras Sutcu Imam University Medical Faculty, Kahramanmaras, Türkiye., Terzioğlu Öztürk S; Department of Pediatrics, Kahramanmaras Sutcu Imam University Medical Faculty, Kahramanmaras, Türkiye., Yeni SN; Division of Clinical Neurophysiology, Department of Neurology, Istanbul University-Cerrahpasa, Cerrahpasa Faculty of Medicine, Istanbul, Türkiye., Özkara Ç; Division of Clinical Neurophysiology, Department of Neurology, Istanbul University-Cerrahpasa, Cerrahpasa Faculty of Medicine, Istanbul, Türkiye., Aksu M; Department of Neurology, Acibadem University Atakent Hospital Medical Faculty, Istanbul, Türkiye., Tüzün E; Department of Neuroscience, Aziz Sancar Institute of Experimental Medicine, Istanbul University, Istanbul, Türkiye., Benbir Şenel G; Division of Clinical Neurophysiology, Department of Neurology, Istanbul University-Cerrahpasa, Cerrahpasa Faculty of Medicine, Istanbul, Türkiye. drgulcinbenbir@yahoo.com.
Jazyk: angličtina
Zdroj: Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology [Neurol Sci] 2024 Nov; Vol. 45 (11), pp. 5429-5439. Date of Electronic Publication: 2024 Jun 24.
DOI: 10.1007/s10072-024-07652-z
Abstrakt: Introduction: Sleep disturbances are being increasingly recognized in association with autoimmune encephalitis (AIE). We investigated the prevalence of sleep-related symptoms and polysomnographic features of patients with AIE and the long-term outcomes in these patients in a multi-center, prospective study from Turkey.
Methods: We prospectively evaluated patients with definite AIE in a common database including demographics, AIE-related and sleep-related symptomatology. Maximum and latest modified Rankin scores (mRS) and Liverpool Outcome Score (LOS) were noted.
Results: Of 142 patients, 87 patients (61.3%) fulfilled the criteria for definite AIE (mean age, 46.8+18.8 years; 51.7% women; mean disease duration, 21.0+38.4 months). 78.9% of patients had at least one or more new onset or worsened sleep-related symptomatology: insomnia (55.3%), excessive daytime sleepiness (EDS, 28.0%), sleep apnea (18.7%), REM sleep behavior disorder (RBD, 17.3%), restless legs syndrome (10.7%) and oneiric stupor (9.3%). Sleep efficiency, N3 and REM sleep were decreased and N1 sleep was increased in patients with Ab[+] AIE. LOS points were highest in those with insomnia and sleep apnea, and lowest in those with EDS, RBD and oneiric stupor. RBD and sleep apnea were more common in anti-LG1 Ab[+] group than anti-NMDAR Ab[+] group. Index of periodic leg movements was highest in anti-LG1 Ab[+] group. Patients with EDS and oneiric stupor had more common memory problems. Maximum and latest mRS scores were positively correlated with EDS and oneiric stupor. EDS, RBD and oneiric stupor were negatively correlated with LOS points.
Conclusion: Our study emphasizes the presence and importance of early diagnosis of sleep disturbances in AIE in regard to their deteriorative influences on disease prognosis.
(© 2024. The Author(s).)
Databáze: MEDLINE
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