The association of microvascular disease and endothelial dysfunction with vertebral trabecular bone mineral density : The MESA study.

Autor: Barzilay JI; Division of Endocrinology, Kaiser Permanente of Georgia, 3650 Steve Reynolds Blvd, Duluth, GA, 30096, USA. joshua.barzilay@kp.org.; Division of Endocrinology, Emory University School of Medicine, Atlanta, GA, USA. joshua.barzilay@kp.org., Buzkova P; Division of Biostatistics, School of Public Health, University of Washington, Seattle, WA, USA., Bielinski SJ; Department of Epidemiology, Mayo Clinic, Rochester, MN, USA., Cotch MF; Office of Vision Health and Population Sciences, National Eye Institute, National Institutes of Health, Bethesda, MD, USA., Kestenbaum B; Division of Nephrology, University of Washington, Seattle, WA, USA., Austin TR; Department of Epidemiology, Cardiovascular Health Research Unit, University of Washington, Seattle, WA, USA., Carbone L; Division of Rheumatology, Medical College of Georgia, Augusta, GA, USA., Mukamal KJ; Department of Medicine, Beth Israel Deaconess Medical Center, Harvard University, Brookline, MA, USA., Budoff MJ; Department of Medicine, Lundquist Institute at Harbor-UCLA, Torrance, CA, USA.
Jazyk: angličtina
Zdroj: Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA [Osteoporos Int] 2024 Sep; Vol. 35 (9), pp. 1595-1604. Date of Electronic Publication: 2024 Jun 24.
DOI: 10.1007/s00198-024-07152-y
Abstrakt: Retinopathy and albuminuria are associated with hip fracture risk. We investigated whether these disorders and endothelial dysfunction (which underlies microvascular diseases) were associated with low trabecular bone density. No significant associations were found, suggesting that microvascular diseases are not related to fracture risk through low trabecular bone density.
Purpose: Microvascular diseases of the eye, kidney, and brain are associated with endothelial dysfunction and increased hip fracture risk. To explore the basis for higher hip fracture risk, we comprehensively examined whether markers of microvascular disease and/or endothelial dysfunction are related to trabecular bone mineral density (BMD), a proximate risk factor for osteoporotic fractures.
Methods: Among 6814 participants in the Multi-Ethnic Study of Atherosclerosis study (MESA), we derived thoracic vertebral trabecular BMD from computed tomography of the chest and measured urine albumin to creatinine ratios (UACR), retinal arteriolar and venular widths, flow mediated dilation (FMD) of the brachial artery after 5 min of ischemia; and levels of five soluble endothelial adhesion markers (ICAM-1, VCAM-1, L-selectin, P-selectin, and E-selectin). Linear regression models were used to examine the association of trabecular BMD with markers of microvascular disease and with markers of endothelial dysfunction.
Results: We observed no significant associations of UACR, retinal arteriolar or venular widths, or FMD with BMD. We also observed no statistically significant association of spine trabecular BMD with levels of endothelial adhesion markers. Men and women had largely similar results.
Conclusion: We conclude that there is little evidence to connect thoracic spine trabecular BMD to microvascular disorders or to endothelial dysfunction among multi-ethnic middle-aged and older adults. Other factors beyond trabecular BMD (e.g., bone quality or predisposition to falling) may be responsible for the associations of microvascular disease with osteoporotic fractures.
(© 2024. International Osteoporosis Foundation and Bone Health and Osteoporosis Foundation.)
Databáze: MEDLINE
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