Do Complications After Pancreatoduodenectomy Have an Impact on Long-Term Quality of Life and Functional Outcomes?

Autor:	Gikandi A; From the Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA., Fong ZV; Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA., Qadan M; Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA., Narayan RR; Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA., Lwin T; Department of Surgery, City of Hope National Medical Center, Duarte, CA., Fernández-Del Castillo C; Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA., Lillemoe KD; Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA., Ferrone CR; Department of Surgery, Cedars-Sinai Medical Center, Los Angeles, CA.
Jazyk:	angličtina
Zdroj:	Annals of surgery open : perspectives of surgical history, education, and clinical approaches [Ann Surg Open] 2024 Mar 26; Vol. 5 (2), pp. e400. Date of Electronic Publication: 2024 Mar 26 (Print Publication: 2024).
DOI:	10.1097/AS9.0000000000000400
Abstrakt:	Objective: Our aim was to assess whether complications after pancreatoduodenectomy (PD) impact long-term quality of life (QoL) and functional outcomes. Background: There is an increasing number of long-term post-PD survivors, but few studies have evaluated long-term QoL outcomes. Methods: The EORTC QLQ-C30 and QLQ-PAN26 questionnaires were administered to patients who survived >5 years post-PD. Clinical relevance (CR) was scored as small (5-10), moderate (10-20), or large (>20). Patients were stratified based on whether they experienced a complication during the index hospitalization. Results: Of 305 patients >5 years post-PD survivors, with valid contact information, 248 completed the questionnaires, and 231 had complication data available. Twenty-nine percent of patients experienced a complication, of which 17 (7.4%) were grade 1, 27 (11.7%) were grade 2, and 25 (10.8%) were grade 3. Global health status and functional domain scores were similar between both groups. Patients experiencing complications reported lower fatigue (21.4 vs 28.1, P < 0.05, CR small) and diarrhea (15.9 vs 23.1, P < 0.05, CR small) symptom scores when compared to patients without complications. Patients experiencing complications also reported lower pancreatic pain (38.2 vs 43.4, P < 0.05, CR small) and altered bowel habits (30.1 vs 40.7, P < 0.01, CR moderate) symptom scores. There was a lower prevalence of worrying (36.2% vs 60.5%, P < 0.05) and bloating (42.0% vs 56.2%, P < 0.05) among PD survivors with complications. Conclusions: Post-PD complication rates were not associated with long-term global QoL or functionality, and may be associated with less severe pancreas-specific symptoms. (Copyright © 2024 The Author(s). Published by Wolters Kluwer Health, Inc.)
Databáze:	MEDLINE
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