Regulatory role of Echinochrome A in cancer-associated fibroblast-mediated lung cancer cell migration.

Autor: Eum DY; Research Center, Dongnam Institute of Radiological & Medical Sciences, Busan, 46033 Republic of Korea.; College of Pharmacy and Research Institute for Drug Development, Pusan National University, Busan, 46241 Republic of Korea., Lee C; Research Center, Dongnam Institute of Radiological & Medical Sciences, Busan, 46033 Republic of Korea., Tran CS; College of Pharmacy and Research Institute for Drug Development, Pusan National University, Busan, 46241 Republic of Korea., Lee J; College of Pharmacy and Research Institute for Drug Development, Pusan National University, Busan, 46241 Republic of Korea., Park SY; Research Center, Dongnam Institute of Radiological & Medical Sciences, Busan, 46033 Republic of Korea., Jeong MS; Research Center, Dongnam Institute of Radiological & Medical Sciences, Busan, 46033 Republic of Korea., Jin Y; Research Center, Dongnam Institute of Radiological & Medical Sciences, Busan, 46033 Republic of Korea., Shim JW; Research Center, Dongnam Institute of Radiological & Medical Sciences, Busan, 46033 Republic of Korea., Lee SR; College of Pharmacy and Research Institute for Drug Development, Pusan National University, Busan, 46241 Republic of Korea.; Research Institute for Drug Development, Pusan National University, Busan, 46241 Republic of Korea., Koh M; Department of Chemistry, Pusan National University, Busan, 46241 Republic of Korea., Vasileva EA; G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Science, 100 Let Vladivostoku Prosp., 159, Vladivostok, 690022 Russia., Mishchenko NP; G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Science, 100 Let Vladivostoku Prosp., 159, Vladivostok, 690022 Russia., Park SJ; Research Center, Dongnam Institute of Radiological & Medical Sciences, Busan, 46033 Republic of Korea., Choi SH; Research Center, Dongnam Institute of Radiological & Medical Sciences, Busan, 46033 Republic of Korea., Choi YJ; Research Center, Dongnam Institute of Radiological & Medical Sciences, Busan, 46033 Republic of Korea., Yun H; College of Pharmacy and Research Institute for Drug Development, Pusan National University, Busan, 46241 Republic of Korea.; Research Institute for Drug Development, Pusan National University, Busan, 46241 Republic of Korea., Heo K; Research Center, Dongnam Institute of Radiological & Medical Sciences, Busan, 46033 Republic of Korea.
Jazyk: angličtina
Zdroj: Toxicological research [Toxicol Res] 2024 Apr 11; Vol. 40 (3), pp. 409-419. Date of Electronic Publication: 2024 Apr 11 (Print Publication: 2024).
DOI: 10.1007/s43188-024-00232-5
Abstrakt: Echinochrome A (Ech A), a marine biosubstance isolated from sea urchins, is a strong antioxidant, and its clinical form, histochrome, is being used to treat several diseases, such as ophthalmic, cardiovascular, and metabolic diseases. Cancer-associated fibroblasts (CAFs) are a component of the tumor stroma and induce phenotypes related to tumor malignancy, including epithelial-mesenchymal transition (EMT) and cancer stemness, through reciprocal interactions with cancer cells. Here, we investigated whether Ech A modulates the properties of CAFs and alleviates CAF-induced lung cancer cell migration. First, we observed that the expression levels of CAF markers, Vimentin and fibroblast-activating protein (FAP), were decreased in Ech A-treated CAF-like MRC5 cells. The mRNA transcriptome analysis revealed that in MRC5 cells, the expression of genes associated with cell migration was largely modulated after Ech A treatment. In particular, the expression and secretion of cytokine and chemokine, such as IL6 and CCL2, stimulating cancer cell metastasis was reduced through the inactivation of STAT3 and Akt in MRC5 cells treated with Ech A compared to untreated MRC5 cells. Moreover, while conditioned medium from MRC5 cells enhanced the migration of non-small cell lung cancer cells, conditioned medium from MRC5 cells treated with Ech A suppressed cancer cell migration. In conclusion, we suggest that Ech A might be a potent adjuvant that increases the efficacy of cancer treatments to mitigate lung cancer progression.
Competing Interests: Conflict of interestThe authors have no relevant financial or nonfinancial interests to disclose.
(© The Author(s) under exclusive licence to Korean Society of Toxicology 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.)
Databáze: MEDLINE
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