Modulation of diabetic wound healing using carbon monoxide gas-entrapping materials.

Autor: Witt E; Department of Biomedical Engineering, University of Iowa, Iowa City, IA, 52242, USA.; Department of Radiation Oncology, University of Iowa, Iowa City, IA, 52242, USA.; Holden Comprehensive Cancer Center, University of Iowa, Iowa City, IA, 52242, USA., Leach AJ; Holden Comprehensive Cancer Center, University of Iowa, Iowa City, IA, 52242, USA.; Carver College of Medicine, University of Iowa, Iowa City, IA, 52242, USA., Bi J; Department of Biomedical Engineering, University of Iowa, Iowa City, IA, 52242, USA.; Department of Radiation Oncology, University of Iowa, Iowa City, IA, 52242, USA.; Holden Comprehensive Cancer Center, University of Iowa, Iowa City, IA, 52242, USA., Hatfield S; Holden Comprehensive Cancer Center, University of Iowa, Iowa City, IA, 52242, USA.; Carver College of Medicine, University of Iowa, Iowa City, IA, 52242, USA., Cotoia AT; Department of Biology and Marine Biology, University of North Carolina Wilmington, Wilmington, NC, 28403, USA., McGovern MK; Department of Biomedical Engineering, University of Iowa, Iowa City, IA, 52242, USA.; Department of Radiation Oncology, University of Iowa, Iowa City, IA, 52242, USA.; Holden Comprehensive Cancer Center, University of Iowa, Iowa City, IA, 52242, USA., Cafi AB; Department of Biomedical Engineering, University of Iowa, Iowa City, IA, 52242, USA.; Department of Radiation Oncology, University of Iowa, Iowa City, IA, 52242, USA.; Holden Comprehensive Cancer Center, University of Iowa, Iowa City, IA, 52242, USA., Rhodes AC; Department of Biomedical Engineering, University of Iowa, Iowa City, IA, 52242, USA.; Department of Radiation Oncology, University of Iowa, Iowa City, IA, 52242, USA.; Holden Comprehensive Cancer Center, University of Iowa, Iowa City, IA, 52242, USA., Cook AN; Department of Biomedical Engineering, University of Iowa, Iowa City, IA, 52242, USA.; Department of Radiation Oncology, University of Iowa, Iowa City, IA, 52242, USA.; Holden Comprehensive Cancer Center, University of Iowa, Iowa City, IA, 52242, USA., Uaroon S; Holden Comprehensive Cancer Center, University of Iowa, Iowa City, IA, 52242, USA.; Department of Otolaryngology, University of Iowa, Iowa City, IA, 52242, USA., Parajuli B; Department of Pathology, University of Iowa, Iowa City, IA, 52242, USA., Kim J; Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, ON M5S 1A8, Canada.; Division of Gastroenterology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA., Feig V; Division of Gastroenterology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA., Scheiflinger A; Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 02215, USA., Nwosu I; Holden Comprehensive Cancer Center, University of Iowa, Iowa City, IA, 52242, USA.; Carver College of Medicine, University of Iowa, Iowa City, IA, 52242, USA., Jimenez M; Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, ON M5S 1A8, Canada.; Division of Gastroenterology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.; Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA., Coleman MC; Free Radical and Radiation Biology Program, University of Iowa, Iowa City, IA, 52242, USA., Buchakjian MR; Holden Comprehensive Cancer Center, University of Iowa, Iowa City, IA, 52242, USA.; Department of Otolaryngology, University of Iowa, Iowa City, IA, 52242, USA., Bosch DE; Holden Comprehensive Cancer Center, University of Iowa, Iowa City, IA, 52242, USA.; Department of Pathology, University of Iowa, Iowa City, IA, 52242, USA., Tift MS; Department of Biology and Marine Biology, University of North Carolina Wilmington, Wilmington, NC, 28403, USA., Traverso G; Division of Gastroenterology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.; Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA., Otterbein LE; Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 02215, USA., Byrne JD; Department of Biomedical Engineering, University of Iowa, Iowa City, IA, 52242, USA.; Department of Radiation Oncology, University of Iowa, Iowa City, IA, 52242, USA.; Holden Comprehensive Cancer Center, University of Iowa, Iowa City, IA, 52242, USA.; Free Radical and Radiation Biology Program, University of Iowa, Iowa City, IA, 52242, USA.
Jazyk: angličtina
Zdroj: Device [Device] 2024 May 17; Vol. 2 (5). Date of Electronic Publication: 2024 Mar 12.
DOI: 10.1016/j.device.2024.100320
Abstrakt: Diabetic wound healing is uniquely challenging to manage due to chronic inflammation and heightened microbial growth from elevated interstitial glucose. Carbon monoxide (CO), widely acknowledged as a toxic gas, is also known to provide unique therapeutic immune modulating effects. To facilitate delivery of CO, we have designed hyaluronic acid-based CO-gas-entrapping materials (CO-GEMs) for topical and prolonged gas delivery to the wound bed. We demonstrate that CO-GEMs promote the healing response in murine diabetic wound models (full-thickness wounds and pressure ulcers) compared to N 2 -GEMs and untreated controls.
Databáze: MEDLINE