Updates on the Diagnostic Use of Ultrasonography Augmented With Perfluorobutane Contrast in Hepatocellular Carcinoma: A Meta-Analysis.

Autor:	Wally SF; Radiology, University of Tabuk, Tabuk, SAU., Albalawi AA Sr; Medicine, University of Tabuk, Tabuk, SAU., Al Madshush AM; Medicine, University of Tabuk, Tabuk, SAU., Aljohani M; General Practice, University of Tabuk, Tabuk, SAU., Alshehri AJ; Medicine and Surgery, University of Tabuk, Tabuk, SAU., Alamrani FM; Medicine and Surgery, University of Tabuk, Tabuk, SAU., Alyahya M; Medicine, University of Tabuk, Tabuk, SAU., Aljohani FS; Radiology, University of Tabuk, Tabuk, SAU., Modrba AY; Medicine, University of Tabuk, Tabuk, SAU., Albalawi RH; Radiology, University of Tabuk, Tabuk, SAU., Abo Draa O; Radiology, University of Tabuk, Tabuk, SAU.
Jazyk:	angličtina
Zdroj:	Cureus [Cureus] 2024 May 23; Vol. 16 (5), pp. e60891. Date of Electronic Publication: 2024 May 23 (Print Publication: 2024).
DOI:	10.7759/cureus.60891
Abstrakt:	To investigate the diagnostic accuracy of contrast-enhanced ultrasound (CEUS) in the diagnosis of primary hepatocellular carcinoma (HCC), a thorough search was conducted for pertinent literature using PubMed, SCOPUS, Web of Science, Science Direct, and Wiley Library. This was a meta-analysis of diagnostic test accuracy. MetaDiSc 1.4 was used for all analyses and assessed statistical heterogeneity with the I2 index and the chi-square test. The random-effects model was applied where there was considerable heterogeneity. Using the eight elements of the Newcastle-Ottawa Scale (NOS) for cohort and case-control studies, we assessed the quality of the included studies. Our results included nine studies with a total of 2598 patients, and 1607 (61.8%) were males. The pooled overall sensitivity of perfluorobutane with CEUS was 85.6% (95% CI 0.832, -0.878, and P=0.000) and specificity was 91.5% (95% CI 0.899, -0.930, and P=0.000) with significant inter heterogeneity between studies (I2=94.3% and 95.7%), respectively. The pooled positive likelihood ratio was 12.42 (4.59 to 33.61, P=0.000). Our analysis revealed a symmetric summary receiver operating characteristic (SROC) curve and seven of the included studies are near the top left corner of the graph, indicating that this test has a high diagnostic value. The results showed that CEUS augmented with perfluorobutane contrast had good diagnostic accuracy (sensitivity and specificity) for primary HCC. Further real-world data studies are needed to confirm the good diagnosis accuracy of perfluorobutane CEUS in primary HCC. Competing Interests: The authors have declared that no competing interests exist. (Copyright © 2024, Wally et al.)
Databáze:	MEDLINE
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