Expression of Interleukin-8, Interleukin-12 and Interleukin-13 in Esophageal Squamous Cell Carcinoma: Biomarker Potentiality and Prognostic Significance.

Autor: Talukdar J; Department of Bioengineering and Technology, Gauhati University, Gawahati, Assam, India., Malik A; Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia., Kataki K; Department of Bioengineering and Technology, Gauhati University, Gawahati, Assam, India., Choudhury BN; Department of Gastroentrology, Gauhati Medical College and Hospital, Guwahati, Assam, India., Baruah MN; Department of Head and Neck Oncology, North East Cancer Hospital and Research Institute, Jorabat, Assam, India., Bhattacharyya M; Department of Gastroentrology, Gauhati Medical College and Hospital, Guwahati, Assam, India., Sarma MP; Program of Biotechnology, Faculty of Science, Assam down town University, Guwahati, Assam, India., Bhattacharjee M; Program of Biotechnology, Faculty of Science, Assam down town University, Guwahati, Assam, India., Basak M; Faculty of Pharmaceutical Sciences, Assam down town University, Guwahati, Assam, India., Kashyap MP; Program of Statistics, Faculty of Science, Assam down town University, Guwahati, Assam, India., Bhattacharjee S; Department of Statistics, Gauhati University, Gawahati, Assam, India., Ali E; Department of Bioengineering and Technology, Gauhati University, Gawahati, Assam, India., Keppen C; Department of Bioengineering and Technology, Gauhati University, Gawahati, Assam, India., Kalita S; Department of Bioengineering and Technology, Gauhati University, Gawahati, Assam, India.; Multidisciplinary Research Unit, Diphu Medical College and Hospital, Karbi Anglong, Assam, India., Kalita MJ; Department of Bioengineering and Technology, Gauhati University, Gawahati, Assam, India., Das PP; Multidisciplinary Research Unit, Fakhruddin Ali Ahmed Medical College and Hospital, Barpeta, Assam, India., Hazarika G; Department of Bioengineering and Technology, Gauhati University, Gawahati, Assam, India., Deka AJ; Department of Bioengineering and Technology, Gauhati University, Gawahati, Assam, India., Dutta K; Department of Bioengineering and Technology, Gauhati University, Gawahati, Assam, India., Idris MG; Department of Bioengineering and Technology, Gauhati University, Gawahati, Assam, India., Akhtar S; A. T. Still University of Health Sciences, Kirksville, MO, USA., Medhi S; Department of Bioengineering and Technology, Gauhati University, Gawahati, Assam, India. subhashmedhi@gauhati.ac.in.
Jazyk: angličtina
Zdroj: Journal of gastrointestinal cancer [J Gastrointest Cancer] 2024 Sep; Vol. 55 (3), pp. 1239-1255. Date of Electronic Publication: 2024 Jun 23.
DOI: 10.1007/s12029-024-01063-1
Abstrakt: Purpose: Interleukin-8 (IL8), Interleukin-12 (IL12) and Interleukin-13 (IL13) are cytokines that play regulatory role in cancer pathogenesis. We analysed their expression profile to evaluate as molecular biomarkers of esophageal squamous cell carcinoma (ESCC) and their association with different parameters and patient survival.
Methods: Expression analysis was performed by Real time quantitative polymerase chain reaction and receiver operating characteristic (ROC) curve analysis was done. The expression profiles were associated with different clinicopathological and dietary factors. Survival and hazard analysis were also performed.
Results: IL8 expression showed upregulation in tissue (p = 0.000) and blood samples (p = 0.481), IL12 expression showed downregulation in tissue samples (p = 0.064) and upregulation in blood samples (p = 0.689) and IL13 expression showed upregulation in tissue (p = 0.000) and blood samples (p = 0.006). IL13 expression in tissue showed the highest area under the curve (AUC) value (0.773) for ESCC diagnosis, followed by IL8 expression in tissue (0.704) and IL13 expression in blood (0.643). This study also reveals the correlation of studied cytokines in tissue and blood level. Different clinicopathological and dietary factors showed significant association (p < 0.05) with IL8, IL12 and IL13 expression and with survival of ESCC patients. IL8 expression in blood and IL12 expression in tissue and blood showed significant association (p < 0.05) with patient survival.
Conclusion: Altered expression of IL8, IL12 and IL13 may be associated with ESCC progression. Overexpression of IL8 and IL13 in tissue samples may be potential biomarkers for ESCC screening. Additionally, both survival and hazard analysis data indicate the effects of different parameters on the prognosis of ESCC patients.
(© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
Externí odkaz: