Causal relationship between basal metabolic rate and intervertebral disc degeneration: a Mendelian randomization study.

Autor: Liu Z; Department of Spine Surgery, The First College of Clinical Medical Science, China Three Gorges University, Yichang, Hubei, 443002, China.; Department of Orthopaedics, Affiliated Hospital of Jiujiang University, Jiujiang, Jiangxi, 443003, China.; Central Laboratory, The First College of Clinical Medical Science China Three Gorges University, China Three Gorges University, Yichang, Hubei, 443003, China., Cai H; Department of Hematology, The First College of Clinical Medical Science China Three Gorges University, China Three Gorges University, Yichang, Hubei, 443003, China., Zhou Z; Department of Spine Surgery, The First College of Clinical Medical Science, China Three Gorges University, Yichang, Hubei, 443002, China.; Ningxia Medical University, Yinchuan, Ningxia, 443003, China., Chen S; Department of Spine Surgery, The First College of Clinical Medical Science, China Three Gorges University, Yichang, Hubei, 443002, China., Yang D; Department of Spine Surgery, The First College of Clinical Medical Science, China Three Gorges University, Yichang, Hubei, 443002, China., Zhuo C; Department of Spine Surgery, The First College of Clinical Medical Science, China Three Gorges University, Yichang, Hubei, 443002, China., Chen H; Department of Spine Surgery, The First College of Clinical Medical Science, China Three Gorges University, Yichang, Hubei, 443002, China. wenquanchd@sina.com.; Ningxia Medical University, Yinchuan, Ningxia, 443003, China. wenquanchd@sina.com.
Jazyk: angličtina
Zdroj: European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society [Eur Spine J] 2024 Sep; Vol. 33 (9), pp. 3352-3358. Date of Electronic Publication: 2024 Jun 24.
DOI: 10.1007/s00586-024-08367-7
Abstrakt: Background: The role of basal metabolic rate (BMR) in intervertebral disc degeneration (IVDD) is still uncertain. To address this gap, we conducted a Mendelian randomization (MR) study to comprehensively explore the causal relationship between BMR and IVDD.
Methods: BMR data were obtained from a large genome-wide association study (GWAS) database, while IVDD data were derived from the FinnGen project. The causal relationship between IVDD and BMR was investigated using MR, with inverse-variance weighting (IVW) as the primary estimate. MR-Egger weighed median and weighed mode were employed for robustness. Sensitivity analyses, including the Cochran Q test, leave-one-out analysis, and MR-Egger intercept analysis, were conducted. Furthermore, the study also identified causal relationships between IVDD and factors associated with BMR (hyperthyroidism, type 2 diabetes, standing height, weight, and body mass index). Multivariable MR was applied to further assess the direct effect of BMR on IVDD.
Results: Genetic predisposition to BMR (after removing outliers OR: 1.49; 95% CI: 1.37-1.63; P = 5.073e-21) were associated with an increased risk of IVDD. Additionally, IVDD risk increased with greater height, weight, and BMI. No causal relationship was observed between hy/thy and T2D and intervertebral disc degeneration (IVDD) (P > 0.05). In multivariable MR, a significant causal association between BMR and IVDD persisted, even after adjusting for BMI, height, and weight.
Conclusion: In this study, we successfully identified that a higher BMR is independently and causally linked to IVDD, indicating an increased risk of developing IVDD. These findings suggest that managing BMR could potentially mitigate the risk of IVDD.
(© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
Databáze: MEDLINE
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