NEK-mediated barrier regulation.

Autor: Barabutis N; School of Basic Pharmaceutical and Toxicological Sciences, College of Pharmacy, University of Louisiana Monroe, Monroe, LA, 71201, USA. Electronic address: barabutis@ulm.edu.
Jazyk: angličtina
Zdroj: Pulmonary pharmacology & therapeutics [Pulm Pharmacol Ther] 2024 Sep; Vol. 86, pp. 102313. Date of Electronic Publication: 2024 Jun 21.
DOI: 10.1016/j.pupt.2024.102313
Abstrakt: Endothelial dysfunction has been associated with devastating outcomes which can eventually lead to permanent disability and death. Elucidation of the meticulously devised network orchestrating endothelial responses, provides information to develop new therapies towards endothelial-related disorders. NEK kinases - which have been involved in the development of human disease - promote vascular leak; suggesting the possibility that their inhibition may ameliorate medical conditions related to barrier derangement.
Competing Interests: Declaration of competing interest The author declares no conflict of interest.
(Copyright © 2024 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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