The glucosylamine oxidation pathway of vitamin C recycling.

Autor: Hempe JM; Department of Pediatrics, Louisiana State University Health Sciences Center, New Orleans, LA, USA. Electronic address: jhempe@lsuhsc.edu., Hsia DS; Pennington Biomedical Research Center, Baton Rouge, LA, USA; Department of Pediatrics, Division of Endocrinology, Emory University School of Medicine, Atlanta, GA, USA., Hagar A; Georgia Public Health Laboratory, Atlanta, GA, USA., Byers L; Department of Chemistry, Tulane University, New Orleans, LA, USA.
Jazyk: angličtina
Zdroj: Journal of diabetes and its complications [J Diabetes Complications] 2024 Aug; Vol. 38 (8), pp. 108797. Date of Electronic Publication: 2024 Jun 19.
DOI: 10.1016/j.jdiacomp.2024.108797
Abstrakt: The proposed glucosylamine oxidation pathway (GOP) is a two-step, intraerythrocyte, thermodynamically favorable nonenzymatic reaction that first binds glucose to the N-terminal valine of beta globin (βVal1) to form a closed-chain glucosylamine that can spontaneously reduce oxidized vitamin C to its antioxidant form. This review summarizes analytical, biochemical and clinical research supporting the existence of the GOP and the surprising hypothesis that βVal1 glucosylamine is a reducing agent that works cooperatively with reduced glutathione to dynamically regulate vitamin C recycling during naturally occurring periods of transiently or chronically elevated blood glucose and oxidant production. Rationale for the existence of the GOP is presented from the perspective of the hemoglobin glycation index, a clinically practical biomarker of risk for chronic vascular disease that we propose is mechanistically explained by person-to-person variation in GOP activity.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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