Genomic predictors of physical activity and athletic performance.

Autor:	Ahmetov II; Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, United Kingdom; Sports Genetics Laboratory, St Petersburg Research Institute of Physical Culture, St. Petersburg, Russia; Laboratory of Genetics of Aging and Longevity, Kazan State Medical University, Kazan, Russia; Department of Physical Education, Plekhanov Russian University of Economics, Moscow, Russia. Electronic address: genoterra@mail.ru., John G; Transform Specialist Medical Centre, Dubai, United Arab Emirates., Semenova EA; Department of Molecular Biology and Genetics, Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, Moscow, Russia; Research Institute of Physical Culture and Sport, Volga Region State University of Physical Culture, Sport and Tourism, Kazan, Russia., Hall ECR; Faculty of Health Sciences and Sport, University of Stirling, Stirling, United Kingdom.
Jazyk:	angličtina
Zdroj:	Advances in genetics [Adv Genet] 2024; Vol. 111, pp. 311-408. Date of Electronic Publication: 2024 Feb 15.
DOI:	10.1016/bs.adgen.2024.01.001
Abstrakt:	Physical activity and athletic performance are complex phenotypes influenced by environmental and genetic factors. Recent advances in lifestyle and behavioral genomics led to the discovery of dozens of DNA polymorphisms (variants) associated with physical activity and allowed to use them as genetic instruments in Mendelian randomization studies for identifying the causal links between physical activity and health outcomes. On the other hand, exercise and sports genomics studies are focused on the search for genetic variants associated with athlete status, sports injuries and individual responses to training and supplement use. In this review, the findings of studies investigating genetic markers and their associations with physical activity and athlete status are reported. As of the end of September 2023, a total of 149 variants have been associated with various physical activity traits (of which 42 variants are genome-wide significant) and 253 variants have been linked to athlete status (115 endurance-related, 96 power-related, and 42 strength-related). (Copyright © 2024. Published by Elsevier Inc.)
Databáze:	MEDLINE
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