A 20-year serological survey of Toxoplasma gondii and Neospora caninum infection in dogs with neuromuscular disorders from urban areas in Argentina.

Autor: Gos ML; Immunoparasitology Laboratory (LAINPA), Faculty of Veterinary Science, La Plata National University, 60 and 118 s/n, La Plata, Buenos Aires 1900, Argentina; Parasitology and Parasitic Diseases, Faculty of Veterinary Science, La Plata National University, 60 and 118 s/n, La Plata, Buenos Aires 1900, Argentina., Venturini MC; Immunoparasitology Laboratory (LAINPA), Faculty of Veterinary Science, La Plata National University, 60 and 118 s/n, La Plata, Buenos Aires 1900, Argentina., De Felice L; Immunoparasitology Laboratory (LAINPA), Faculty of Veterinary Science, La Plata National University, 60 and 118 s/n, La Plata, Buenos Aires 1900, Argentina; Parasitology and Parasitic Diseases, Faculty of Veterinary Science, La Plata National University, 60 and 118 s/n, La Plata, Buenos Aires 1900, Argentina., Dellarupe A; Immunoparasitology Laboratory (LAINPA), Faculty of Veterinary Science, La Plata National University, 60 and 118 s/n, La Plata, Buenos Aires 1900, Argentina; National Scientific and Technical Research Council (CONICET), Godoy Cruz 2290, Buenos Aires C1033AAJ, Argentina. Electronic address: andrea.dellarupe@gmail.com., Rambeaud M; Immunoparasitology Laboratory (LAINPA), Faculty of Veterinary Science, La Plata National University, 60 and 118 s/n, La Plata, Buenos Aires 1900, Argentina., Pardini L; Immunoparasitology Laboratory (LAINPA), Faculty of Veterinary Science, La Plata National University, 60 and 118 s/n, La Plata, Buenos Aires 1900, Argentina; National Scientific and Technical Research Council (CONICET), Godoy Cruz 2290, Buenos Aires C1033AAJ, Argentina., Campero LM; National Scientific and Technical Research Council (CONICET), Godoy Cruz 2290, Buenos Aires C1033AAJ, Argentina; Institute of Innovation for Agricultural Production and Sustainable Development (IPADS Balcarce), Ruta 226 km 73.5, Balcarce, Buenos Aires 7620, Argentina., Bernstein M; Immunoparasitology Laboratory (LAINPA), Faculty of Veterinary Science, La Plata National University, 60 and 118 s/n, La Plata, Buenos Aires 1900, Argentina; National Scientific and Technical Research Council (CONICET), Godoy Cruz 2290, Buenos Aires C1033AAJ, Argentina., Bacigalupe D; Zoonosis Departament, Municipality of Rauch, Rivadavia 750, Rauch, Buenos Aires B7203, Argentina., Basso W; Institute of Parasitology, Department of Infectious Diseases and Pathobiology, Vetsuisse-Faculty, University of Bern, Länggassstrasse 122, Bern 3012, Switzerland., Moré G; Immunoparasitology Laboratory (LAINPA), Faculty of Veterinary Science, La Plata National University, 60 and 118 s/n, La Plata, Buenos Aires 1900, Argentina; Institute of Parasitology, Department of Infectious Diseases and Pathobiology, Vetsuisse-Faculty, University of Bern, Länggassstrasse 122, Bern 3012, Switzerland., Unzaga JM; Immunoparasitology Laboratory (LAINPA), Faculty of Veterinary Science, La Plata National University, 60 and 118 s/n, La Plata, Buenos Aires 1900, Argentina; Parasitology and Parasitic Diseases, Faculty of Veterinary Science, La Plata National University, 60 and 118 s/n, La Plata, Buenos Aires 1900, Argentina.
Jazyk: angličtina
Zdroj: Veterinary parasitology [Vet Parasitol] 2024 Aug; Vol. 330, pp. 110235. Date of Electronic Publication: 2024 Jun 12.
DOI: 10.1016/j.vetpar.2024.110235
Abstrakt: Toxoplasma gondii and Neospora caninum infections may be associated with neuromuscular disorders in dogs. The aim of this study was to assess the seroprevalence to these protozoan parasites in dogs with neuromuscular disease from urban areas of Buenos Aires province, Argentina, over a period of 20 years, and to evaluate the association of seropositivity and antibody titres with different variables such as sex, breed and age. For this, a total of 7238 serum samples from urban owned dogs were analysed by the indirect fluorescence antibody test (IFAT) for specific IgG antibodies. The observed seropositivity rates were 35.7 % for T. gondii and 25.7 % for N. caninum. Crossbred dogs had a significantly higher seroprevalence for T. gondii than purebred dogs (41 % vs. 29.3 %), while a trend towards significance was observed for N. caninum, which was slightly higher in purebred dogs (26 % vs. 23.6 %). Seroprevalence for both parasites increased with age and was higher in older animals. Regarding the distribution of specific antibody titres, the most frequent IFAT T. gondii titre found was 100 and for N. caninum it was ≥800. For toxoplasmosis, there was no association with age group, and low titres (50, 100 and 200) predominated in all groups. However, for neosporosis, age and titres were significantly associated for one age group, with dogs under 12 months of age having a higher proportion of high titres (400 and 800). The trend in the seroprevalence for T. gondii is increasing over the years and lower antibody titres predominate in the dogs studied, which may be more related to the presence of chronic infections and not necessarily to the clinical signs of the animals. Despite the generally low titres observed for toxoplasmosis in this study, it is important to highlight the high seroprevalence found in our region, as dogs can act as sentinels of environmental contamination and as indicators of possible human infection. In the case of neosporosis, although the trend in seroprevalence in dogs with signs appears to be decreasing over the years, our work shows that higher antibody titres predominate, and are probably related to the clinical signs presented by the dogs. This study provides the most recent epidemiological data and serological profiles of T. gondii and N. caninum infections in a large number of canine sera from urban areas in Argentina, providing relevant information for clinical veterinarians and epidemiologists in order to understand the circulation of the parasites.
Competing Interests: Declaration of Competing Interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Venturini Maria Cecilia reports financial support was provided by UNLP, FONCyT. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: