| Autor: |
Maria Neto R; Center for Natural and Human Sciences, Federal University of ABC - UFABC, Santo André, São Paulo, Brazil., Di Fabio E; Center for Natural and Human Sciences, Federal University of ABC - UFABC, Santo André, São Paulo, Brazil., de Monroe Gonçalves M; Center for Natural and Human Sciences, Federal University of ABC - UFABC, Santo André, São Paulo, Brazil., Mamián López MB; Center for Natural and Human Sciences, Federal University of ABC - UFABC, Santo André, São Paulo, Brazil., Figueiredo Angolini CF; Center for Natural and Human Sciences, Federal University of ABC - UFABC, Santo André, São Paulo, Brazil., Carvalho Veggi P; Department of Chemical Engineering, Institute of Environmental, Chemical and Pharmaceutical Sciences, Universidade Federal de São Paulo, Diadema, São Paulo, Brazil., Tempone AG; Center for Parasitology and Mycology, Adolfo Lutz Institute, São Paulo, Brazil., Martin do Prado J; Engineering, Modeling and Applied Social Sciences Center, Federal University of ABC - UFABC, Santo André, São Paulo, Brazil., Lago JHG; Center for Natural and Human Sciences, Federal University of ABC - UFABC, Santo André, São Paulo, Brazil., da Silva BG; Center for Natural and Human Sciences, Federal University of ABC - UFABC, Santo André, São Paulo, Brazil. |
| Abstrakt: |
Anti- Trypanosoma cruzi activity of compounds from fruits of Schinus terebinthifolius Raddi (pink pepper) were evaluated, using sustainable techniques such as steam distillation (SD) and supercritical fluid extraction (SFE). SD was optimised using a design of experiment and SFE was carried out using supercritical CO 2 solvent (300 bar and 60 °C). Results of the anti- T. cruzi activity showed that the essential oil presented high activity (IC 50 = 4.5 ± 0.3 μg/mL), whereas the supercritical extract had a moderate effect (IC 50 = 19.7 ± 2.9 μg/mL). The differences in the anti- T. cruzi activity can be attributed to the extraction of non-volatile compounds in the SFE, such as moronic and ( Z )-masticadienoic acids. In contrast, SD extracted only volatile compounds such as monoterpenes and sesquiterpenes. Therefore, these results suggest that the volatile compounds from pink pepper are involved with the anti- T. cruzi activity. |
