Genetic variation of TLR3 gene is associated with the outcome of hepatitis b infection in mauritanian patients: case control study.

Autor: Soumbara T; Research Unit on Biomarkers in the Mauritanian Population, Faculty of Sciences and Technology, University of Nouakchott, Nouakchott, Mauritania.; National Institute of Hepato- Virology (INHV), Nouakchott, Mauritania., Bonnet C; Institute of Hearing, Pasteur Institute, INSERM, Paris, 75012, France., Hamed CT; National Institute of Hepato- Virology (INHV), Nouakchott, Mauritania., Veten F; National Institute of Hepato- Virology (INHV), Nouakchott, Mauritania., Hemeyine M; National Institute of Hepato- Virology (INHV), Nouakchott, Mauritania., Fall-Malick FZ; National Institute of Hepato- Virology (INHV), Nouakchott, Mauritania., El Yezid MM; National Institute of Hepato- Virology (INHV), Nouakchott, Mauritania., Diallo A; National Institute of Hepato- Virology (INHV), Nouakchott, Mauritania., Mounah MM; National Institute of Hepato- Virology (INHV), Nouakchott, Mauritania., Houmeida A; Research Unit on Biomarkers in the Mauritanian Population, Faculty of Sciences and Technology, University of Nouakchott, Nouakchott, Mauritania. ahmedhoumeida@gmail.com.
Jazyk: angličtina
Zdroj: BMC infectious diseases [BMC Infect Dis] 2024 Jun 21; Vol. 24 (1), pp. 616. Date of Electronic Publication: 2024 Jun 21.
DOI: 10.1186/s12879-024-09503-w
Abstrakt: Background: Toll-Like receptors (TLRs) play an important role in the immune response during hepatitis B virus (HBV) infection. In this study, we evaluated the association between two SNP variants (TLR3 rs3775290 and TLR4 rs4986790) and susceptibility to chronic HBV infection in Mauritania.
Subjects and Methods: A total of 188 subjects were recruited for this study: 102 chronically infected patients and 86 individuals with spontaneously resolved HBV infection who were considered controls. Targeted PCR products were sequenced using Sanger sequencing.
Results: We found that TLR3 rs3775290 was significantly more frequent in patients with chronic HBV than in the control population (p = 0.03). However, no association was found between the TLR4 rs3775290 polymorphism and chronic infection.
Conclusion: Our results suggest that the TLR3 rs3775290 polymorphism may be a risk factor for susceptibility to chronic HBV infection in the Mauritanian population.
(© 2024. The Author(s).)
Databáze: MEDLINE
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