Serum vitamin D, blood pressure and hypertension risk in the HUNT study using observational and Mendelian randomization approaches.

Autor: Jiang L; Department of Public Health and Nursing, Faculty of Medicine and Health Science, Norwegian University of Science and Technology(NTNU), Postbox 8905, MTFS, N-7491, Trondheim, Norway. lin.jiang@ntnu.no.; Clinic of Cardiology, St. Olavs Hospital, Trondheim, Norway. lin.jiang@ntnu.no., Sun YQ; Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Science, Norwegian University of Science and Technology, Trondheim, Norway.; Department of Pathology, Clinic of Laboratory Medicine, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway.; TkMidt-Center for Oral Health Services and Research, Mid-Norway, Trondheim, Norway., Denos M; Department of Public Health and Nursing, Faculty of Medicine and Health Science, Norwegian University of Science and Technology(NTNU), Postbox 8905, MTFS, N-7491, Trondheim, Norway., Brumpton BM; Clinic of Medicine, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway.; K.G. Jebsen Centre for Genetic Epidemiology, Department of Public Health and Nursing, Norwegian University of Science and Technology, Trondheim, Norway.; HUNT Research Centre, Department of Public Health and Nursing, Norwegian University of Science and Technology, Levanger, Norway., Chen Y; School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, Ottawa, Canada., Malmo V; Clinic of Cardiology, St. Olavs Hospital, Trondheim, Norway.; Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway., Sanderson E; MRC Integrative Epidemiology Unit, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK., Mai XM; Department of Public Health and Nursing, Faculty of Medicine and Health Science, Norwegian University of Science and Technology(NTNU), Postbox 8905, MTFS, N-7491, Trondheim, Norway.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2024 Jun 21; Vol. 14 (1), pp. 14312. Date of Electronic Publication: 2024 Jun 21.
DOI: 10.1038/s41598-024-64649-6
Abstrakt: Limited studies have triangulated the relationship between serum 25-hydroxyvitamin D [25(OH)D] levels and systolic blood pressure (SBP), diastolic blood pressure (DBP) or hypertension risk utilizing both observational and Mendelian randomization (MR) approaches. We employed data from the Norwegian Trøndelag Health Study (HUNT) to conduct cross-sectional (n = 5854) and prospective (n = 3592) analyses, as well as one-sample MR (n = 86,324). We also used largest publicly available data for two-sample MR. Our cross-sectional analyses showed a 25 nmol/L increase in 25(OH)D was associated with a 1.73 mmHg decrease in SBP (95% CI - 2.46 to - 1.01), a 0.91 mmHg decrease in DBP (95% CI - 1.35 to - 0.47) and 19% lower prevalence of hypertension (OR 0.81, 95% CI 0.74 to 0.90) after adjusting for important confounders. However, these associations disappeared in prospective analyses. One-sample and two-sample MR results further suggested no causal relationship between serum vitamin D levels and blood pressure or hypertension risk in the general population.
(© 2024. The Author(s).)
Databáze: MEDLINE
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