Cordyceps militaris: A novel mushroom platform for metabolic engineering.

Autor: Zeng J; Institute of Food Biotechnology & College of Food Science, South China Agricultural University, Guangzhou, Guangdong 510642, China; Research Center for Micro-Ecological Agent Engineering and Technology of Guangdong Province, Guangzhou 510642, China., Zhou Y; Institute of Food Biotechnology & College of Food Science, South China Agricultural University, Guangzhou, Guangdong 510642, China; Research Center for Micro-Ecological Agent Engineering and Technology of Guangdong Province, Guangzhou 510642, China., Lyu M; Institute of Food Biotechnology & College of Food Science, South China Agricultural University, Guangzhou, Guangdong 510642, China; Research Center for Micro-Ecological Agent Engineering and Technology of Guangdong Province, Guangzhou 510642, China., Huang X; Institute of Food Biotechnology & College of Food Science, South China Agricultural University, Guangzhou, Guangdong 510642, China; Research Center for Micro-Ecological Agent Engineering and Technology of Guangdong Province, Guangzhou 510642, China., Xie M; School of Bioengineering, Zunyi Medical University, Zhuhai, Guangdong 519090, China., Huang M; School of Food Science and Engineering, South China University of Technology, Guangzhou, Guangdong 510641, China. Electronic address: huangmt@scut.edu.cn., Chen BX; School of Bioengineering, Zunyi Medical University, Zhuhai, Guangdong 519090, China. Electronic address: baixiong@zmu.edu.cn., Wei T; Institute of Food Biotechnology & College of Food Science, South China Agricultural University, Guangzhou, Guangdong 510642, China; Research Center for Micro-Ecological Agent Engineering and Technology of Guangdong Province, Guangzhou 510642, China. Electronic address: weitao@scau.edu.cn.
Jazyk: angličtina
Zdroj: Biotechnology advances [Biotechnol Adv] 2024 Sep; Vol. 74, pp. 108396. Date of Electronic Publication: 2024 Jun 19.
DOI: 10.1016/j.biotechadv.2024.108396
Abstrakt: Cordyceps militaris, widely recognized as a medicinal and edible mushroom in East Asia, contains a variety of bioactive compounds, including cordycepin (COR), pentostatin (PTN) and other high-value compounds. This review explores the potential of developing C. militaris as a cell factory for the production of high-value chemicals and nutrients. This review comprehensively summarizes the fermentation advantages, metabolic networks, expression elements, and genome editing tools specific to C. militaris and discusses the challenges and barriers to further research on C. militaris across various fields, including computational biology, existing DNA elements, and genome editing approaches. This review aims to describe specific and promising opportunities for the in-depth study and development of C. militaris as a new chassis cell. Additionally, to increase the practicability of this review, examples of the construction of cell factories are provided, and promising strategies for synthetic biology development are illustrated.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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