Neurologic Quality of Life Outcomes in Patients with Normal Pressure Hydrocephalus After Ventriculoperitoneal Shunt Placement: A Prospective Assessment of Cognition, Mobility, and Social Participation.

Autor: Caruso JP; Department of Neurological Surgery, UT Southwestern Medical Center, Dallas, Texas, USA. Electronic address: James.Caruso@PHHS.org., El Ahmadieh TY; Department of Neurological Surgery, Loma Linda Medical Center, Loma Linda, California, USA., Trent T; Department of Neurological Surgery, UT Southwestern Medical Center, Dallas, Texas, USA., Stutzman SE; Department of Neurological Surgery, UT Southwestern Medical Center, Dallas, Texas, USA., Anderson R; Department of Neurological Surgery, UT Southwestern Medical Center, Dallas, Texas, USA., Schneider N; Department of Neurological Surgery, UT Southwestern Medical Center, Dallas, Texas, USA., Woodruff C; Department of Neurological Surgery, UT Southwestern Medical Center, Dallas, Texas, USA., Adenwalla A; Department of Neurological Surgery, UT Southwestern Medical Center, Dallas, Texas, USA., Wang J; Department of Neurological Surgery, UT Southwestern Medical Center, Dallas, Texas, USA., Almekkawi AK; Department of Neurological Surgery, University of Missouri - Kansas City, Kansas City, Missouri, USA., Venkatachalam A; Department of Neurological Surgery, UT Southwestern Medical Center, Dallas, Texas, USA., Olson DM; Department of Neurological Surgery, UT Southwestern Medical Center, Dallas, Texas, USA., Aoun SG; Department of Neurological Surgery, UT Southwestern Medical Center, Dallas, Texas, USA., White JA; Department of Neurological Surgery, UT Southwestern Medical Center, Dallas, Texas, USA.
Jazyk: angličtina
Zdroj: World neurosurgery [World Neurosurg] 2024 Oct; Vol. 190, pp. e26-e33. Date of Electronic Publication: 2024 Jun 19.
DOI: 10.1016/j.wneu.2024.06.068
Abstrakt: Background: Idiopathic normal pressure hydrocephalus (iNPH) typically presents with gait disturbances, cognitive decline, and urinary incontinence. Symptomatic improvement generally occurs following shunt placement, but limited evidence exists on the quality of life (QOL) metrics in iNPH. Therefore, we conducted a prospective study of the effect of shunt placement on QOL in iNPH patients, using Quality of Life in Neurologic Disorders (Neuro-QOL) metrics.
Methods: Eligible patients underwent shunt placement after evidence of symptomatic improvement following temporary cerebrospinal fluid diversion via inpatient lumbar drain trial. Patients were administered short- and long-form Neuro-QOL assessments prior to shunt placement and at 6-month and 1-year postoperative timepoints to evaluate lower extremity mobility, cognitive function, and social roles and activities participation. Changes in QOL measures were analyzed using a repeated-measures linear mixed effects model.
Results: There were 48 patients with a mean age of 75.4 ± 6.3 years. Average short-form mobility scores improved by 3.9 points (14.6%) at 6-month follow-up and by 6.2 points (23.2%) at 1-year follow-up compared with preoperative baseline (P = 0.027 and P = 0.0002, respectively). Short-form cognition scores increased by 5.2 points (22.4%) at 6 months and 10.9 points (47.0%) at 1 year postoperatively (P = 0.007 and P < 0.0001, respectively). On long-form assessment, social roles and activity participation scores improved by 29.3 points (23.4%) at 6 months and 31.6 points (25.2%) at 1 year after surgery compared to baseline (P = 0.028 and P = 0.02, respectively).
Conclusions: Our findings demonstrate that shunt placement leads to improved QOL in iNPH patients across multiple domains. Significant improvements in mobility, cognition, and social roles and activity participation are realized within the first 6 months and are sustained on 1-year follow-up.
(Copyright © 2024 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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