Rising trend of symptomatic infections due to Hepatitis A virus infection in adolescent and adult age group: An observational study from a tertiary care liver institute in India.

Autor: Grover M; Department of Clinical Virology, Institute of Liver and Biliary Sciences, New Delhi, India. Electronic address: malika.grover111@gmail.com., Gupta E; Department of Clinical Virology, Institute of Liver and Biliary Sciences, New Delhi, India. Electronic address: ektagaurisha@gmail.com., Samal J; Department of Clinical Virology, Institute of Liver and Biliary Sciences, New Delhi, India. Electronic address: samaljasmine@gmail.com., Prasad M; Department of Epidemiology and Clinical Research, Institute of Liver & Biliary Sciences, New Delhi, India. Electronic address: manya.2311@gmail.com., Prabhakar T; Department of Epidemiology and Clinical Research, Institute of Liver & Biliary Sciences, New Delhi, India. Electronic address: tusharprabhakar90@gmail.com., Chhabra R; Department of Clinical Virology, Institute of Liver and Biliary Sciences, New Delhi, India. Electronic address: ruchitachhabra13@gmail.com., Agarwal R; Department of Clinical Virology, Institute of Liver and Biliary Sciences, New Delhi, India. Electronic address: agarwalreshu286@gmail.com., Raghuvanshi BB; Department of Pediatric Hepatology, Institute of Liver and Biliary Sciences, New Delhi, India. Electronic address: bikrant18may@gmail.com., Sharma MK; Department of Hepatology, Institute of Liver and Biliary Sciences, New Delhi, India. Electronic address: drmanojksharma@ilbs.in., Alam S; Department of Pediatric Hepatology, Institute of Liver and Biliary Sciences, New Delhi, India. Electronic address: seema_alam@hotmail.com.
Jazyk: angličtina
Zdroj: Indian journal of medical microbiology [Indian J Med Microbiol] 2024 Jul-Aug; Vol. 50, pp. 100653. Date of Electronic Publication: 2024 Jun 21.
DOI: 10.1016/j.ijmmb.2024.100653
Abstrakt: Background: Hepatitis A Virus (HAV) is the most common cause of Acute Viral Hepatitis (AVH) in children. It causes self-limiting illness and rarely acute liver failure. The shifting pattern in HAV endemicity is rendering adolescents and adults vulnerable to infection.
Methods: In this retrospective study, samples received from 14,807 patients with acute onset icteric illness from January 2014-December 2022 were analyzed. HAV infection was detected by anti-HAV IgM positivity. The cases were divided into 3 age groups, pediatric, adolescents and adults, and clinical presentations were compared.
Results: Overall, 7.72%(1144) were positive for anti-HAV IgM. Of these, 60%(690) were finally included in the study. The positive cases were divided into adults, ≥18 years (44%, 304); pediatric, <12 years (31%, 212) and adolescents (25%,174) age groups. Overall males were predominant [72.4%(500)], with a median age of 16 (IQR:9-21) years. Cases were characterised into AVH (68.1%, 470/690), Acute Liver Failure (ALF) (31.4%, 217/690) and Acute-on-Chronic Liver Failure (0.43%, 3/690). AVH in the pediatric age group was 69%(146/212), adolescents was 67%(117/174), and adults was 68%(207/304). ALF cases among the 3 groups were 30%(65/212), 33%(57/174), and 31%(95/304) respectively. Overall mortality was seen in 6.52%(45/690), maximum in adolescents with ALF presentation [10.3%(18/174)]. On molecular characterization of infection, viremia was seen in 28.9%(200/690) and all the isolates were Genotype IIIA.
Conclusions: The number of adults experiencing symptomatic HAV infection was seen to increase over the years in the present study. Infection in adolescents was associated with higher mortality and ALF as the clinical presentation.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Indian Association of Medical Microbiologists. Published by Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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