Modulation of cholesterol metabolism with Phytoremedies in Alzheimer's disease: A comprehensive review.

Autor: Koppula S; College of Biomedical and Health Sciences, Konkuk University, Chungju-Si, Chungcheongbuk Do 27478, Republic of Korea. Electronic address: sushrutak@gmail.com., Wankhede NL; Smt. Kishoritai Bhoyar College of Pharmacy, Kamptee, Nagpur, Maharashtra 441002, India. Electronic address: nitu.wankhede211994@gmail.com., Sammeta SS; National Institute of Pharmaceutical Education and Research, Hyderabad, Telangana 500037, India. Electronic address: shivkumarsammeta@gmail.com., Shende PV; Smt. Kishoritai Bhoyar College of Pharmacy, Kamptee, Nagpur, Maharashtra 441002, India. Electronic address: prajwalishende25@gmail.com., Pawar RS; Smt. Kishoritai Bhoyar College of Pharmacy, Kamptee, Nagpur, Maharashtra 441002, India. Electronic address: pawarrupali327@gmail.com., Chimthanawala N; Institute of Chemical Technology, Mumbai 400019, India. Electronic address: niyamataqua@gmail.com., Umare MD; Smt. Kishoritai Bhoyar College of Pharmacy, Kamptee, Nagpur, Maharashtra 441002, India. Electronic address: mohitumare@gmail.com., Taksande BG; Smt. Kishoritai Bhoyar College of Pharmacy, Kamptee, Nagpur, Maharashtra 441002, India. Electronic address: brijeshtaksande@gmail.com., Upaganlawar AB; SNJB's Shriman Sureshdada Jain College of Pharmacy, Neminagar, Chandwad, Nashik, Maharashtra, India. Electronic address: amanrxy@gmail.com., Umekar MJ; Smt. Kishoritai Bhoyar College of Pharmacy, Kamptee, Nagpur, Maharashtra 441002, India. Electronic address: drmilindumekar@gmail.com., Kopalli SR; Department of Bioscience and Biotechnology, Sejong University, Gwangjin-gu, Seoul 05006, Republic of Korea. Electronic address: spandanak@sejong.ac.kr., Kale MB; Smt. Kishoritai Bhoyar College of Pharmacy, Kamptee, Nagpur, Maharashtra 441002, India. Electronic address: mayur.kale28@gmail.com.
Jazyk: angličtina
Zdroj: Ageing research reviews [Ageing Res Rev] 2024 Aug; Vol. 99, pp. 102389. Date of Electronic Publication: 2024 Jun 19.
DOI: 10.1016/j.arr.2024.102389
Abstrakt: Alzheimer's disease (AD) is a complex neurological ailment that causes cognitive decline and memory loss. Cholesterol metabolism dysregulation has emerged as a crucial element in AD pathogenesis, contributing to the formation of amyloid-beta (Aβ) plaques and tau tangles, the disease's hallmark neuropathological characteristics. Thus, targeting cholesterol metabolism has gained attention as a potential therapeutic method for Alzheimer's disease. Phytoremedies, which are generated from plants and herbs, have shown promise as an attainable therapeutic option for Alzheimer's disease. These remedies contain bioactive compounds like phytochemicals, flavonoids, and polyphenols, which have demonstrated potential in modulating cholesterol metabolism and related pathways. This comprehensive review explores the modulation of cholesterol metabolism by phytoremedies in AD. It delves into the role of cholesterol in brain function, highlighting disruptions observed in AD. Additionally, it examines the underlying molecular mechanisms of cholesterol-related pathology in AD. The review emphasizes the significance of phytoremedies as a potential therapeutic intervention for AD. It discusses the drawbacks of current treatments and the need for alternative strategies addressing cholesterol dysregulation and its consequences. Through an in-depth analysis of specific phytoremedies, the review presents compelling evidence of their potential benefits. Molecular mechanisms underlying phytoremedy effects on cholesterol metabolism are examined, including regulation of cholesterol-related pathways, interactions with Aβ pathology, influence on tau pathology, and anti-inflammatory effects. The review also highlights challenges and future perspectives, emphasizing standardization, clinical evidence, and personalized medicine approaches to maximize therapeutic potential in AD treatment. Overall, phytoremedies offer promise as a potential avenue for AD management, but further research and collaboration are necessary to fully explore their efficacy, safety, and mechanisms of action.
Competing Interests: Declaration of Competing Interest None Declared
(Copyright © 2024 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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