Association of T-cell subtypes with macrophage-specific arterial infiltration in people with HIV.

Autor:	Schnittman SR; Division of Infectious Diseases, Department of Medicine.; Metabolism Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA., Talathi R; Metabolism Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA., Wilks MQ; Yale PET Center, Yale School of Medicine, New Haven, CT., Hedgire S; Cardiovascular Imaging Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA., Lu MT; Cardiovascular Imaging Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA., Fourman LT; Metabolism Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA., Alagpulinsa DA; Yale Center for Molecular and Systems Metabolism & Department of Comparative Medicine, Yale School of Medicine, New Haven, CT., Stockman SL; Metabolism Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA., White KS; Biology Department, Boston College, Chestnut Hill., Wallis ZK; Biology Department, Boston College, Chestnut Hill., Autissier P; Biology Department, Boston College, Chestnut Hill., Stanley TL; Metabolism Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA., Lee H; Biostatistics Center, Massachusetts General Hospital and Harvard Medical School., Honigberg MC; Cardiovascular Research Center, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., El-Fakhri G; Yale PET Center, Yale School of Medicine, New Haven, CT., Williams KC; Biology Department, Boston College, Chestnut Hill., Zanni MV; Metabolism Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA., Grinspoon SK; Metabolism Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA., Toribio M; Metabolism Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA.
Jazyk:	angličtina
Zdroj:	AIDS (London, England) [AIDS] 2024 Nov 15; Vol. 38 (14), pp. 1940-1946. Date of Electronic Publication: 2024 Jun 20.
DOI:	10.1097/QAD.0000000000003967
Abstrakt:	People with human immunodeficiency virus (HIV, PWH) face an increased risk of cardiovascular disease (CVD) compared to the general population. We previously demonstrated that people with (versus without) HIV have higher macrophage-specific arterial infiltration in relation to systemic monocyte activation. We now show that select T lymphocyte subpopulations (naïve CD4 + , effector memory CD4 + , and central memory CD8 + ) are differentially associated with macrophage-specific arterial infiltration among participants with versus without HIV, with evidence of interaction by HIV status. Our results suggest that among PWH, circulating T lymphocytes associate with macrophage-specific arterial infiltration, of relevance to atherogenesis and CVD risk. (Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.)
Databáze:	MEDLINE
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