| Autor: |
Gao M; Interdisciplinary Materials Research Center, School of Materials Science and Engineering, Tongji Univ., 4800 Caoan Rd., Shanghai 201804, China. liwen@tongji.edu.cn., Luo Y; Department of Orthopedics, Shanghai Tenth People's Hospital, School of Medicine, Tongji Univ., 301 Yanchang Rd., Shanghai 200072, China. dr.zheng@tongji.edu.cn.; Orthopedic Intelligent Minimally Invasive Diagnosis and Treatment Center, Shanghai Tenth People's Hospital, School of Medicine, Tongji Univ., 301 Yanchang Rd., Shanghai 200072, China., Li W; Interdisciplinary Materials Research Center, School of Materials Science and Engineering, Tongji Univ., 4800 Caoan Rd., Shanghai 201804, China. liwen@tongji.edu.cn., Zheng L; Department of Orthopedics, Shanghai Tenth People's Hospital, School of Medicine, Tongji Univ., 301 Yanchang Rd., Shanghai 200072, China. dr.zheng@tongji.edu.cn.; Orthopedic Intelligent Minimally Invasive Diagnosis and Treatment Center, Shanghai Tenth People's Hospital, School of Medicine, Tongji Univ., 301 Yanchang Rd., Shanghai 200072, China., Pei Y; Interdisciplinary Materials Research Center, School of Materials Science and Engineering, Tongji Univ., 4800 Caoan Rd., Shanghai 201804, China. liwen@tongji.edu.cn. |
| Abstrakt: |
The ability of thermoelectric materials to generate electricity in response to local temperature gradients makes them a potentially promising solution for the regulation of cellular functions and reconstruction of tissues. Biocompatibility of implants is a crucial attribute for the successful integration of thermoelectric techniques in biomedical applications. This work focuses on the in vitro and in vivo evaluation of biocompatibility for 12 typical chalcogenide thermoelectrics, which are composed of biocompatible elements. Ag 2 Se, SnSe, Bi 2 Se 3 , Bi 2 Te 2.88 Se 0.12 and Bi 2 Te 3 , each with a released ion concentration lower than 10 ppm in extracts, exhibited favorable biocompatibility, including cell viability, adhesion, and hemocompatibility, as observed in initial in vitro assessments. Moreover, in vivo biocompatibility assessment, achieved by hematological and histopathological analyses in the rat subcutaneous model, further substantiated the biocompatibility of Ag 2 Se, Bi 2 Se 3 , and Bi 2 Te 3 , with each possessing superior thermoelectric performance at room temperature. This work offers robust evidence to promote Ag 2 Se, Bi 2 Se 3 , and Bi 2 Te 3 as potential thermoelectric biomaterials, establishing a foundation for their future applications in biomedicine. |
