Relation between interleukin-13 and annexin-V levels and carotid intima-media thickness in nephrotic syndrome.

Autor:	Elsehmawy AA; Pediatric Department, Al-Azhar University, Cairo - Egypt., Gouda RM; Pediatric Department, Al-Azhar University, Cairo - Egypt., Diab FEAE; Clinical Pathology Department, Al-Azhar University, Cairo - Egypt., Saleh OI; Radiology Department, Al-Azhar University, Cairo - Egypt., Galal HM; Radiology Department, Al-Azhar University, Cairo - Egypt., Al Anany MG; Physiology Department, Al-Azhar University, Cairo - Egypt.; Armed Forces College of Medicine, Cairo - Egypt., Abd Elgawad SS; Pediatric Department, Al-Azhar University, Cairo - Egypt., Hassan MM; Community Medicine Department, Al-Azhar University, Cairo - Egypt., Kamal MAM; Clinical Pathology Department, Al-Azhar University, Cairo - Egypt., Elamir AY; Radiology Department, Cairo University, Cairo - Egypt.
Jazyk:	angličtina
Zdroj:	Journal of circulating biomarkers [J Circ Biomark] 2024 Jun 18; Vol. 13, pp. 7-13. Date of Electronic Publication: 2024 Jun 18 (Print Publication: 2024).
DOI:	10.33393/jcb.2024.2689
Abstrakt:	Background and Aim: The aim of the current study is to assess the relation between carotid intima-media thickness (CIMT) measurements, renal Doppler resistive index (RI) and serum levels of interleukin-13 (IL-13) and annexin-V (An-V) in children with idiopathic nephrotic syndrome (INS). Materials and Methods: The present case-control study was conducted on 60 children with INS and 60 age- and sex-matched healthy children. All participants were subjected to evaluation of serum levels of IL-13 and An-V and ultrasound Doppler measurement of CIMT and renal RI. Results: Patients expressed significantly higher An-V (5.9 ± 2.6 vs. 2.1 ± 0.8 ng/mL, p<0.001) and IL-13 (19.2 ± 7.6 vs. 3.4 ± 1.4 ng/L) levels when compared with healthy counterparts. Moreover, it was shown that patients had significantly higher CIMT (0.49 ± 0.06 vs. 0.35 ± 0.03, p<0.001) as compared to controls. No significant differences were noted between the studied groups regarding right or left RIs. Correlation analysis identified significant direct correlation between serum An-V levels and albumin/creatinine ratio (ACR) (r = 0.55), cholesterol (r = 0.48), triglycerides (r = 0.36), IL-13 (r = 0.92) and CIMT (r = 0.53). Similar correlations could be found between serum IL-13 levels and CIMT measurements and the corresponding parameters. Conclusions: The present study suggests an association between higher early atherosclerosis expressed as elevated CIMT measurements in children with INS and elevated serum levels of An-V and IL-13. (© 2024 The Authors.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu