The effect of porang ( Amorphophallus muelleri ) extract on renal histopathological changes.

Autor: Ricardo E; Undergraduate Program (Student), Faculty of Medicine, Widya Mandala Surabaya Catholic University, Surabaya, Indonesia., Novita BD; Department of Pharmacology and Therapy, Faculty of Medicine, Widya Mandala Surabaya Catholic University, Surabaya, Indonesia., Suwasanti N; Department of Clinical Pathology, Faculty of Medicine, Widya Mandala Surabaya Catholic University, Surabaya, Indonesia., Muliyanto JA; Undergraduate Program (Student), Faculty of Medicine, Widya Mandala Surabaya Catholic University, Surabaya, Indonesia., Dewi IGAPDM; Undergraduate Program (Student), Faculty of Medicine, Widya Mandala Surabaya Catholic University, Surabaya, Indonesia., Jaya F; Undergraduate Program (Student), Faculty of Medicine, Widya Mandala Surabaya Catholic University, Surabaya, Indonesia.
Jazyk: angličtina
Zdroj: Journal of advanced pharmaceutical technology & research [J Adv Pharm Technol Res] 2024 Apr-Jun; Vol. 15 (2), pp. 86-90. Date of Electronic Publication: 2024 May 06.
DOI: 10.4103/JAPTR.JAPTR_426_23
Abstrakt: Diabetes mellitus is a chronic condition defined by elevated blood sugar levels (hyperglycemia). This condition can lead to complications such as nephropathy, which is histologically shown with glomerulosclerosis. Glucomannan, a component of Amorphophallus muelleri , offers numerous health benefits, but its direct therapeutic effect on glomeruli remains uncertain. Male Wistar rats which were taken with random sampling ( n = 30) were distributed into six distinct groups. All groups, excluding Group N, received 125 mg/kg BW single intraperitoneal dose of alloxan. Group N received a single dose of PBS 125 mg/kg BW. After 7 days, Group K + was induced with acarbose at a dose of 50 mg/70 kg BW (adjusted using a factor of 0.018) orally per day. Groups N and K - induced with 1% CMC Na at 0.2 mL/0.1 kg orally per day. While Group P1, P2, and P3 were orally given A. muelleri ethanolic extract orally per day at a dose of 100, 200, and 400 mg/kg BW. The following 50 days of treatment, the Wistar rats were euthanized, and their kidney was preserved for histological slides that were stained with hematoxylin and eosin. The oral administration of A. muelleri ethanolic extract in alloxan-induced diabetic rats led to a significant decrease in the average of glomerulosclerosis instances when compared to the K - group. The most effective dose was observed at 400 mg/kg BW per day. A. muelleri administration leads to a reduction in glomerulosclerosis occurrences, suggesting its potential as a therapeutic approach for reducing complications probability linked to hyperglycemia.
Competing Interests: There are no conflicts of interest.
(Copyright: © 2024 Journal of Advanced Pharmaceutical Technology & Research.)
Databáze: MEDLINE
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